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Morgagni-Stewart-Morel syndrome

Other Names for this Disease
  • Hyperostosis frontalis interna, obesity, shortness and cognitive impairment
  • MSM syndrome
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Morgagni-Stewart-Morel (MSM) syndrome is a condition characterized by thickening of the frontal bone of the skull (hyperostosis frontalis interna), as well as obesity and excessive hair growth (hypertrichosis) in some individuals.[1] Other signs and symptoms may include seizures, headaches, diabetes insipidus, and sex gland disturbances.[2] The cause of Morgagni-Stewart-Morel syndrome is not fully understood. Some instances of dominant inheritance have been reported, but whether it is autosomal dominant or X-linked dominant is not known.[3]
Last updated: 3/25/2011


  1. Morgagni-Stewart-Morel syndrome. Orphanet. June 2006; Accessed 3/25/2011.
  2. Hyperostosis Frontalis Interna. NORD. 2007; Accessed 3/25/2011.
  3. Victor A. McKusick et al. HYPEROSTOSIS FRONTALIS INTERNA. OMIM. 1986-2009; Accessed 3/25/2011.
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Basic Information

  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • MeSH® (Medical Subject Headings) is a terminology tool used by the National Library of Medicine. Click on the link to view information on this topic.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Morgagni-Stewart-Morel syndrome. Click on the link to view a sample search on this topic.