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Genetic and Rare Diseases Information Center (GARD)

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Systemic mastocytosis

Other Names for this Disease
  • Agressive systemic mastocytosis
  • Indolent systemic mastocytosis
  • Mast cell leukemia
  • SMCD
  • Systemic mast cell disease
More Names
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Your Question

My mother is suffering from systemic mastocytosis. What types of treatment are available for this condition?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

How might systemic mastocytosis be treated?

Treatment for systemic mastocytosis is based on each individual's symptoms. This includes efforts to control anaphylaxis and other allergic reactions, itching (pruritus) and flushing, and intestinal malabsorption.[1]  Some of the  medications used to treat systemic mastocytosis include:[2]

  • Antihistamines to treat itching, other skin complaints, severe flushing and low blood pressure before symptoms appear, and ulcers;
  • Proton pump inhibitors to relieve ulcer-like symptoms;
  • Epinephrine to treat symptom flares which occur with shock, referred to as anaphylaxis;
  • Steroids to treat malabsorption (impaired ability to take in nutrients); and  
  • Cromolyn sodium which may help reduce cramping in the abdomen.

In cases in which mastocytosis is malignant, cancerous, or associated with a blood disorder, steroids and/or chemotherapy may be necessary.[2]

More specific information about treatment options can be accessed through the Treatment and Medication sections of the Medscape Reference web site.

Last updated: 10/5/2012