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Myelofibrosis

Other Names for this Disease
  • Agnogenic myeloid metaplasia
  • Idiopathic myelofibrosis
  • Myeloid metaplasia
  • Primary myelofibrosis
More Names
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Overview


Myelofibrosis is a disorder of the bone marrow, in which the marrow is replaced by fibrous (scar) tissue.[1] Scarring of the bone marrow causes anemia, which can lead to fatigue and weakness, as well as pooling of the blood in abnormal sites like the liver and spleen, causing these organs to swell.[1][2] Although myelofibrosis can occur at any age, it typically develops after the age of 50.[1][2] In most cases, myelofibrosis gets progressively worse. Treatment is aimed at relieving signs and symptoms and may include medications, blood transfusions, chemotherapy, radiation therapy and surgery.[2]   

References

  1. Dugdale DC, Mason JR. Primary myelofibrosis. MedlinePlus. http://www.nlm.nih.gov/medlineplus/ency/article/000531.htm. Accessed January 7, 2008.
  2. Myelofibrosis. MayoClinic.com. http://www.mayoclinic.com/print/myelofibrosis/DS00886/DSECTION=all&METHOD=print. Accessed January 7, 2008.
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General Information

  • The CMPD Education Foundation provides online information on myeloproliferative disorders (MPD). Click on the link to view the resource.
  • Genetics Home Reference (GHR) contains information on Myelofibrosis. Click on the link to go to GHR and review the information.
  • MayoClinic.com offers additional information about myelofibrosis. Click on the above link to access this information.
  • MedlinePlus, a Web site designed by the National Library of Medicine to help you research your health questions, provides more information about this topic. Click on the link to view this information.
  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Leukemia & Lymphoma Society has an article on idiopathic myelofibrosis. Click on Leukemia & Lymphoma Society to view the article.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Myelofibrosis. Click on the link to view a sample search on this topic.
  • The The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Myelofibrosis. Click on the link to go to OMIM and review these resources.