Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Good syndrome


Other Names for this Disease

  • Immunodeficiency with thymoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Good syndrome is a rare, adult-onset primary immunodeficiency suspected in patients who exhibit hypogammaglobulinemia and low levels of B cells along with a benign thymic tumor (thymoma) on chest X-ray.[1][2][3] Symptoms include frequent opportunistic infections involving the sinuses and lungs, including severe CMV disease, P. carinii pneumonia, and mucocutaneous candidiasis.[2][3] While the cause of Good syndrome remains unknown, there is some evidence that a defect of the bone marrow is involved.[3] Treatment includes removal of the thymic tumor and immunoglobulin replacement.[1][2][3]
Last updated: 10/31/2012

References

  1. Other Important Primary Immunodeficiency Diseases. Immune Deficiency Foundation. 2011; http://primaryimmune.org/about-primary-immunodeficiency-diseases/types-of-pidd/other-important-primary-immunodeficiency-diseases. Accessed 12/6/2011.
  2. Tarr PE, Sneller MC, Mechanic LJ, Economides A, Eger CM, Strober W, Cunningham-Rundles C, Lucey DR. Infections in patients with immunodeficiency with thymoma (Good syndrome). Report of 5 cases and review of the literature. Medicine (Baltimore). 2001; http://www.ncbi.nlm.nih.gov/pubmed/11307588. Accessed 12/6/2011.
  3. P Kelleher, SA Misbah. What is Good’s syndrome? Immunological abnormalities in patients with thymoma. J Clin Pathol . 2003; http://jcp.bmj.com/content/56/1/12.full. Accessed 12/6/2011.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

1 question(s) from the public on Good syndrome have been answered. See questions and answers. You can also submit a new question.
On this page

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Good syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Immunodeficiency with thymoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.