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Good syndrome

Other Names for this Disease
  • Immunodeficiency with thymoma
More Names
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Overview


Good syndrome is a rare, adult-onset primary immunodeficiency suspected in patients who exhibit hypogammaglobulinemia and low levels of B cells along with a benign thymic tumor (thymoma) on chest X-ray.[1][2][3] Symptoms include frequent opportunistic infections involving the sinuses and lungs, including severe CMV disease, P. carinii pneumonia, and mucocutaneous candidiasis.[2][3] While the cause of Good syndrome remains unknown, there is some evidence that a defect of the bone marrow is involved.[3] Treatment includes removal of the thymic tumor and immunoglobulin replacement.[1][2][3]

References

  1. Other Important Primary Immunodeficiency Diseases. Immune Deficiency Foundation. http://primaryimmune.org/about-primary-immunodeficiency-diseases/types-of-pidd/other-important-primary-immunodeficiency-diseases. Accessed December 6, 2011.
  2. Tarr PE, Sneller MC, Mechanic LJ, Economides A, Eger CM, Strober W, Cunningham-Rundles C, Lucey DR. Infections in patients with immunodeficiency with thymoma (Good syndrome). Report of 5 cases and review of the literature. Medicine (Baltimore). 2001. http://www.ncbi.nlm.nih.gov/pubmed/11307588. Accessed December 6, 2011.
  3. P Kelleher, SA Misbah. What is Good’s syndrome? Immunological abnormalities in patients with thymoma. J Clin Pathol . 2003. http://jcp.bmj.com/content/56/1/12.full. Accessed December 6, 2011.
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  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The National Institute of Allergy and Infectious Diseases (NIAID) supports scientists developing better ways to diagnose, treat, and prevent the many infectious, immunologic, and allergic diseases that afflict people worldwide. You can contact NIAID for more information on this topic by calling 301-496-5717 or by visiting their Web site.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Good syndrome. Click on the link to view a sample search on this topic.