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Good syndrome

Other Names for this Disease
  • Immunodeficiency with thymoma
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Good syndrome is a rare, adult-onset primary immunodeficiency suspected in patients who exhibit hypogammaglobulinemia and low levels of B cells along with a benign thymic tumor (thymoma) on chest X-ray.[1][2][3] Symptoms include frequent opportunistic infections involving the sinuses and lungs, including severe CMV disease, P. carinii pneumonia, and mucocutaneous candidiasis.[2][3] While the cause of Good syndrome remains unknown, there is some evidence that a defect of the bone marrow is involved.[3] Treatment includes removal of the thymic tumor and immunoglobulin replacement.[1][2][3]
Last updated: 10/31/2012


  1. Other Important Primary Immunodeficiency Diseases. Immune Deficiency Foundation. 2011; Accessed 12/6/2011.
  2. Tarr PE, Sneller MC, Mechanic LJ, Economides A, Eger CM, Strober W, Cunningham-Rundles C, Lucey DR. Infections in patients with immunodeficiency with thymoma (Good syndrome). Report of 5 cases and review of the literature. Medicine (Baltimore). 2001; Accessed 12/6/2011.
  3. P Kelleher, SA Misbah. What is Good’s syndrome? Immunological abnormalities in patients with thymoma. J Clin Pathol . 2003; Accessed 12/6/2011.
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