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Genetic and Rare Diseases Information Center (GARD)

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Non-A-E hepatitis

Other Names for this Disease
  • Hepatitis X
  • Viral hepatitis non-A,-B,-C,-D,-E
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Your Question

I am trying to find information about transmission of hepatitis X.  Is it found in Europe or just the USA?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is non-A-E hepatitis?

Non-A-E hepatitis, sometimes referred to as hepatitis X, is a disease of the liver that is diagnosed when there is swelling of the liver (hepatitis) but examination and testing does not identify a cause.  Symptoms of non-A-E hepatitis may include feeling tired or unwell (malaise), nausea, vomiting, pain in the abdomen, and fever.  Non-A-E hepatitis usually goes away on its own, but it can become a chronic condition in a small proportion (12%) of affected individuals.  The cause of non-A-E hepatitis is currently unknown.[1]
Last updated: 8/16/2012

How does an individual become affected by non-A-E hepatitis?

The cause of non-A-E hepatitis has not yet been discovered.  Some researchers suggest that there are likely several unidentified infectious agents, such as unknown viruses, that may cause this disease.  Individuals affected by this condition have not consistently been found to have exposures to known risk factors for hepatitis (such as having dental work or medical procedures, working in health care, or traveling to areas where hepatitis is common).[1][2][3]
Last updated: 8/16/2012

In what countries has non-A-E hepatitis been found?

Non-A-E hepatitis has been identified in individuals worldwide.[2]
Last updated: 8/16/2012

  • Delic D, Mitrovic N, Spurnic AR, Svirtlih NS, Babic JS. Epidemiological characteristics and clinical manifestations of acute non-A-E hepatitis. Vojnosanitetsky Pregled. 2010; 67:903-909. Accessed 8/16/2012.
  • Chu CM, Lin DY, Yeh CT, Sheen IS, Liaw YF. Epidemiological characteristics, risk factors, and clinical manifestations of acute non-A-E hepatitis. Journal of Medical Virology. 2001; 65:296-300. Accessed 8/16/2012.
  • Alter MJ, Gallagher M, Morris TT, Moyer LA, Meeks EL, Krawczynski K, Kim JP, Margolis HS. Acute non-A-E hepatitis in the United States and the role of hepatitis G virus infection. Sentinel Counties Viral Hepatitis Study Team. New England Journal of Medicine. 1997; 336:741-746. Accessed 8/16/2012.