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Genetic and Rare Diseases Information Center (GARD)

Other Names for this Disease
  • Choreoathetosis familial paroxysmal
  • DYT8
  • Familial paroxysmal choreoathetosis
  • FPD1
  • Mount-Reback syndrome
More Names
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Paroxysmal nonkinesigenic dyskinesia is a disorder of the nervous system that causes periods of involuntary movement. Common symptoms include 1 to 4 hour long episodes of irregular, jerking or shaking movements, prolonged contraction of muscles, chorea, and/or writhing movements of the limb. The movements may have no known trigger or be brought on by alcohol, caffeine, stress, fatigue, menses, or excitement.  The familial form is caused by mutations in the PNKD gene and is inherited in an autosomal dominant pattern.[1]
Last updated: 11/24/2008


  1. Familial paroxysmal nonkinesigenic dyskinesia. Genetics Home Reference. 2008; Accessed 11/24/2008.
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  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
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