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Autoimmune progesterone dermatitis

Other Names for this Disease
  • APD
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Autoimmune progesterone dermatitis (APD) is a rare condition characterized by a cyclic skin rash which develops premenstrually in women. The condition usually occurs in adulthood after the start of periods (menarche), and rarely during pregnancy or postmenopause.[1] Signs and symptoms vary among affected individuals; skin findings that have been reported include hives, erythema multiforme, papulovesicles (an eczema-like rash), annular erythema, angiodema, mouth erosions and pruritus (itching).[1][2] The rash typically begins a few days before menses and subsides around the time menstruation begins, recurring at the next cycle.[2] The exact cause is unknown, but is thought to involve a hypersensitivity reaction to a woman's own progesterone.[3] Depending on the severity, treatment may include topical medications, systemic corticosteroids, hormone therapy to inhibit the production of progesterone, or surgical removal of the ovaries.[2]
Last updated: 1/9/2012


  1. TuEgba Oskay, Lale Kutluay, Asli Kaptanocglu, Onur Karabacak. Autoimmune progesterone dermatitis. European Journal of Dermatology. November-December 2002; 12(6):589-591.
  2. Autoimmune progesterone dermatitis. DermNet NZ. December 9, 2009; Accessed 1/6/2011.
  3. Tami Maguire. Autoimmune Progesterone Dermatitis. Dermatology Nursing. 2009; 21(4):190-192. Accessed 1/9/2012.
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Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.

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