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Genetic and Rare Diseases Information Center (GARD)

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Eosinophilic enteropathy

Other Names for this Disease
  • Eosinophilic enteritis
  • Eosinophilic esophagitis
  • Eosinophilic gastritis
  • Eosinophilic gastroenteritis
  • Eosinophilic gastroenteropathy
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Tests & Diagnosis

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How is eosinophilic enteropathy diagnosed?

Endoscopy and biopsy is the only way to confirm the diagnosis of eosinophilic enteropathy. During an endoscopy, a gastroenterologist looks at the gastrointestinal tract through an endoscope and takes multiple small samples (biopsies), which a pathologist reviews. A high number of eosinophils suggests the diagnosis of eosinophilic enteropathy. The pathologist will also look at the location of the eosinophils, changes in the tissue layers, and degranulation (spilling of the contents of the eosinophils). Eosinophils may be normally found in small numbers in all areas of the gastrointestinal tract except the esophagus. However, the number of eosinophils seen in individuals with eosinophilic enteropathy is much higher. Once the diagnosis of eosinophilic enteropathy is confirmed, food allergy testing is typically recommended to guide treatment. Tests for food allergies include skin prick testing, patch testing, and a Radioallergosorbent test (RAST).[1]
Last updated: 2/25/2011

  1. Learn more about Eosinophilic Disorders. American Partnership for Eosinophilic Disorders. April 1, 2006; Accessed 2/25/2011.