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Other Names for this Disease
- Hereditary hypotrichosis simplex
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the scalp-limited form and the generalized form, in which all body hair is affected. The progressive thinning of the hair shaft is a typical feature of androgenetic alopecia. Hypotrichosis simplex can be inherited either as an autosomal dominant or autosomal recessive trait. Some cases are caused by mutations in the APCDD1 gene on chromosome 18p11. To date, there is no treatment for this condition.Hypotrichosis simplex is a rare form of hereditary hair loss without other abnormalities. Affected individuals typically show normal hair at birth, but experience hair loss and thinning of the hair shaft that starts during early childhood and progresses with age. Hypotrichosis simplex can be divided into 2 forms:
Last updated: 7/12/2011
- Hypotrichosis simplex, Generalized, Heriditary. Online Mendelian Inheritance in Man (OMIM). 2011; http://omim.org/entry/605389. Accessed 7/12/2011.
- Betz RC. Hypotrichosis simplex. Orphanet. 2010; http://www.orphanet.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=55654. Accessed 7/12/2011.
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In Depth Information
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Hypotrichosis simplex. Click on the link to go to OMIM and review these resources.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Hypotrichosis simplex. Click on the link to view a sample search on this topic.