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Genetic and Rare Diseases Information Center (GARD)

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Pyridoxine-dependent epilepsy

Other Names for this Disease
  • Pyridoxine dependency
  • Pyridoxine dependency with seizures
  • Vitamin B6-dependent seizures
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How might pyridoxine-dependent epilepsy be treated?

Anticonvulsant drugs, which are usually given to control seizures, are ineffective in people with pyridoxine-dependent epilepsy. Instead, people with this type of seizure are medically treated with large daily doses of pyridoxine (a type of vitamin B6 found in food).[1][2] Recent studies have focused on using a lysine-restricted diet in addition to pyridoxine. Preliminary results suggest that this treatment has the potential to help control seizures and improve developmental outcomes in children with pyridoxine-dependent epilepsy.[3]
Last updated: 7/23/2013

  1. Pyridoxine-dependent epilepsy. Genetics Home Reference (GHR). 2013; Accessed 7/23/2013.
  2. Gospe SM. Pyridoxine-Dependent Seizures. GeneReviews. 2012; Accessed 7/23/2013.
  3. van Karnebeek CD et al. Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials. Mol Genet Metab. 2012 Nov;107(3):335-44. .

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