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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Monilethrix


Other Names for this Disease

  • Nodose hair
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Symptoms

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What are the characteristics of monilethrix?

Monilethrix is characterized by a beaded appearance of the hair due to periodic thinning of the shaft. This condition results in hair fragility and patchy dystrophic alopecia (hair loss). The term monilethrix is derived from the Latin word monile, which means necklace, and the Greek word thrix, which means hair. This term describes the resemblance of the hair to a string of beads or a necklace.[1]
Last updated: 1/30/2012

The Human Phenotype Ontology provides the following list of signs and symptoms for Monilethrix. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.


What parts of the body does monilethrix affect?

Monilethrix occurs mainly on the scalp, predominantly on the occiput and nape and occasionally on other scalp areas. Scalp involvement can be widespread or localized. Occasionally, the eyelashes, eyebrows, pubic, axillary, and limb hair are involved.[1]
Last updated: 1/30/2012

The Human Phenotype Ontology provides the following list of signs and symptoms for Monilethrix. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Abnormality of the eyebrow 90%
Abnormality of the nail 90%
Alopecia 90%
Fine hair 90%
Hyperkeratosis 90%
Slow-growing hair 90%
Abnormality of the teeth 50%
Abnormality of the anterior chamber 7.5%
Abnormality of the oral cavity 7.5%
Abnormality of the respiratory system 7.5%
Behavioral abnormality 7.5%
Cafe-au-lait spot 7.5%
Cataract 7.5%
Cognitive impairment 7.5%
Inflammatory abnormality of the eye 7.5%
Leukemia 7.5%
Seizures 7.5%
Visual impairment 7.5%
Abnormality of metabolism/homeostasis -
Autosomal dominant inheritance -
Brittle hair -
Heterogeneous -
Hypotrichosis -
Infantile onset -
Nail dysplasia -
Nail dystrophy -
Perifollicular hyperkeratosis -
Variable expressivity -

Last updated: 9/2/2014

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. Schwartz RA, Alexiewicx-Slowinska M. Monilethrix. Medscape Reference. September 12, 2013; http://emedicine.medscape.com/article/1118500-overview#. Accessed 3/12/2014.


Other Names for this Disease
  • Nodose hair
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.