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Plasma cell leukemia

Other Names for this Disease
  • Leukemia, plasma cell
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Plasma cell leukemia (PCL) is a rare and aggressive form of multiple myeloma that involves high levels of plasma cells circulating in the peripheral blood. The signs and symptoms of PCL include aggressive clinical features, such as extramedullary disease, bone marrow failure, advanced stage disease and expression of distinct immunophenotypic markers.[1] Different types of treatments are available for patients with PCL. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. For detailed information on the available treatment options, please visit the following link.
Last updated: 2/20/2014


  1. Michaela Liedtke, Bruno C Medeiros. Plasma Cell Leukemia: Concepts and Management. Expert Rev Hematol. 2010; 3(5):543-549. Accessed 2/19/2014.
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Basic Information

  • The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.  Click on the link to view information on this topic. 

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  • UpToDate has an article on Plasma cell leukemia. Click on UpToDate to view the page.