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Fibrolamellar hepatocellular carcinoma
Other Names for this Disease
- Eosinophilic glassy cell hepatoma
- Eosinophilic hepatocellular carcinoma with lamellar fibrosis
- Fibrolamellar carcinoma
- Fibrolamellar oncocytic hepatoma
- Fibrolamellar variant of hepatocellular carcinoma
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Fibrolamellar carcinoma is an uncommon malignant tumor that originates in the liver. This variant of hepatocellular carcinoma differs from conventional hepatocellular carcinoma in aetiology (cause), demographics, condition of the affected liver, and tumor markers. This entity typically occurs in young adults (ages 20 to 40) with no underlying hepatitis or cirrhosis. In addition, the serum levels of alpha-fetoprotein are usually not elevated in patients with fibrolamellar hepatocellular carcinoma. Surgery is currently the most effective means of treating and controlling fibrolamellar variant cancer. While there is some debate about the issue, fibrolamellar variant carcinoma may have a better outlook (prognosis) than other forms of liver cancer.
Last updated: 10/28/2010
- Bhaijee F, Locketz ML, Krige JE. S Afr J Surg. 2009; http://www.ncbi.nlm.nih.gov/pubmed/20141066. Accessed 10/28/2010.
- What is Fibrolamellar?. Fibrolamellar Cancer Foundation. http://www.fibrofoundation.org/page10.php. Accessed 10/28/2010.
- Liver Cancer Overview. American Cancer Society. 2010; http://www.cancer.org/Cancer/LiverCancer/OverviewGuide/liver-cancer-overview-what-is-liver-cancer. Accessed 10/28/2010.
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- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Fibrolamellar hepatocellular carcinoma. Click on the link to go to OMIM and review these resources.
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