Other Names for this Disease
- Calcifying epithelioma of Malherbe
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
On this page
The cause of all pilomatrixomas is not fully known, but investigators have shown that at least 75% of individuals with pilomatrixomas have mutations in the CTNNB1 gene. This gene is responsible for a protein that is needed to regulate cell growth and attachment. When the gene is not working properly, it can result in abnormal cell growth. It is thought that the tumors typically arise from cells that interact with hair follicle cells.
Last updated: 12/1/2010
- Jaggi Rao, Andrew Lin. Pilomatrixoma. Emedicine. May 21, 2010; http://emedicine.medscape.com/article/1058965-overview. Accessed 12/1/2010.
- CTNNB1. Genetics Home Reference. November 28, 2010; http://ghr.nlm.nih.gov/gene/CTNNB1. Accessed 12/1/2010.
- Pirouzmanesh A, Reinisch JF, Gonzalez-Gomez I, Smith EM, Meara JG. Pilomatrixoma: a review of 346 cases. Plastic and Reconstructive Surgery. December 2003; 112(7):1784-1789. http://www.ncbi.nlm.nih.gov/pubmed/14663221. Accessed 12/1/2010.