Alzheimer disease type 2
Other Names for this Disease
- Alzheimer disease associated with APOE E4
- Late onset Alzheimer disease
- Late onset familial Alzheimer disease
Your QuestionI once heard that Alzheimers Disease skips generations. For example, my mother's father suffered from this illness. Does my mother have a higher chance of developing the condition than my brother and I?
We have identified the following information that we hope you find helpful. If you still have questions, please contact us.
Questions on this page
- What is Alzheimer disease?
- Can you tell me my chances of developing Alzheimers disease?
- Can Alzheimer disease be passed through families?
- What is early-onset Alzheimer disease and how is it inherited?
- What is late-onset Alzheimer disease and how is it inherited?
- How can I find a genetics professional in my area?
The remaining cases of Alzheimer disease are familial, which means they are found in multiple members of a family. Familial Alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65).
The remaining 25 percent of Alzheimer disease cases are hereditary, which means they are caused by mutated genes and tend to cluster in families. These cases can be divided into early-onset disease and late-onset disease.
Early-onset Alzheimer disease is often inherited in an autosomal dominant manner, meaning that the risk to offspring of an individual with early-onset familial Alzheimer disease is 50% if a mutation is found in APP, PSEN1, or PSEN2. Occasionally, neither parent is affected, but a second-degree relative (e.g., an uncle, aunt and/or grandparent) has or had early-onset Alzheimer disease.
You can read a comprehensive review of early-onset Alzheimer disease on the GeneReviews Web site.
The following online resources can help you find a genetics professional in your community:
- The National Society of Genetic Counselors provides a searchable directory of US and international genetic counseling services.
- The American College of Medical Genetics has a searchable database of US genetics clinics.
- The University of Kansas Medical Center provides a list of US and international genetic centers, clinics, and departments.
- The American Society of Human Genetics maintains a database of its members, which includes individuals who live outside of the United States. Visit the link to obtain a list of the geneticists in your country, some of whom may be researchers that do not provide medical care.
- Alzheimer Disease. Genetic Home Reference. October 2006; http://ghr.nlm.nih.gov/condition=alzheimerdisease. Accessed 1/18/2008.
- Alzheimer's Facts and Figures. Alzheimer's association. October 16, 2007; http://www.alz.org/alzheimers_disease_facts_figures.asp. Accessed 1/18/2008.
- Alzheimer Disease Overview. GeneReviews. http://www.ncbi.nlm.nih.gov/books/NBK1161/. Accessed 1/25/2008.