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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Alzheimer disease type 2


Other Names for this Disease
  • AD2
  • Alzheimer disease associated with APOE E4
  • Late onset Alzheimer disease
  • Late onset familial Alzheimer disease
  • LOFAD
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Inheritance


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What is late-onset Alzheimer disease and how is it inherited?

Late-onset Alzheimer disease is a form of Alzheimer disease that begins to affect people after the age of 65. The genetic causes of late-onset Alzheimer disease are less clear. No gene that definitely causes the condition has been identified. However, a gene called APOE has been studied extensively as a risk factor for the disease. In particular, one form (or allele) of this gene seems to increase an individual's risk for developing type 2 Alzheimer disease. [1]
Last updated: 7/5/2013

References
  1. Alzheimer Disease Overview. GeneReviews. http://www.ncbi.nlm.nih.gov/books/NBK1161/. Accessed 1/25/2008.