Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Inclusion body myopathy 2


Other Names for this Disease

  • Distal myopathy with rimmed vacuoles
  • DMRV
  • GNE myopathy
  • Hereditary inclusion body myopathy
  • HIBM
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Symptoms

Newline Maker

What are the symptoms of inclusion body myopathy 2?

Inclusion body myopathy 2 causes muscle weakness that appears in late adolescence or early adulthood and worsens over time.The first sign of inclusion body myopathy 2 is often weakness of  the tibialis anterior, a muscle in the lower leg that helps control up-and-down movement of the foot. Weakness in the tibialis anterior alters the way a person walks and makes it difficult to run and climb stairs. As the disorder progresses, weakness also develops in muscles of the upper legs, hips, shoulders, and hands. Unlike most forms of myopathy, inclusion body myopathy 2 usually does not affect the quadriceps (a group of large muscles at the front of the thigh). This condition also spares muscles of the eye or heart, and does not cause neurological problems. Weakness in leg muscles makes walking increasingly difficult, and most people with inclusion body myopathy 2 require wheelchair assistance within 20 years after signs and symptoms appear.[1]
Last updated: 1/13/2014

References
  1. Inclusion body myopathy 2. Genetics Home Reference (GHR). December 2008; http://ghr.nlm.nih.gov/condition/inclusion-body-myopathy-2. Accessed 12/4/2012.


Other Names for this Disease
  • Distal myopathy with rimmed vacuoles
  • DMRV
  • GNE myopathy
  • Hereditary inclusion body myopathy
  • HIBM
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.