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Variant Creutzfeldt-Jakob disease


Other Names for this Disease

  • New variant of CJD
  • Nv-CJD
  • Variant CJD
  • Variant Creutzfeldt-Jacob disease
  • VCJD
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Overview

There are several known variants of Creutzfeldt-Jakob disease (CJD). These variants differ somewhat in the symptoms and course of the disease. For example, a variant form of the disease-called new variant or variant (nv-CJD, v-CJD), described in Great Britain and France, begins primarily with psychiatric symptoms, and has a longer than usual duration from onset of symptoms to death.[1] New variant CJD accounts for less than 1% of cases, and tends to affect younger people. It can result when someone is exposed to contaminated products.[2] While classic CJD is not related to mad cow disease, new variant CJD (nvCJD) is an infectious form that is related to mad cow disease. The infection responsible for the disease in cows (bovine spongiform encephalitis) is believed to be the same one responsible for vCJD in humans.[2][3] There have not been any cases of nvCJD reported in the U.S.[2]

Another variant, called the panencephalopathic form, occurs primarily in Japan and has a relatively long course, with symptoms often progressing for several years. Scientists are trying to gain a better understanding about what causes these variations in the symptoms and course of the disease.[1]
Last updated: 1/28/2009

References

  1. Creutzfeldt-Jakob Disease Fact Sheet. National Institute of Neurological Disorders and Stroke (NINDS). December 9, 2008; http://www.ninds.nih.gov/disorders/cjd/detail_cjd.htm#103193058. Accessed 1/28/2009.
  2. Kantor D. Creutzfeldt-Jakob disease. MedlinePlus. August 6, 2007; http://www.nlm.nih.gov/medlineplus/ency/article/000788.htm. Accessed 1/28/2009.
  3. vCJD (Variant Creutzfeldt-Jakob Disease). National Center for Infectious Diseases: Centers for Disease Control and Prevention (CDC). January 4, 2007; http://www.cdc.gov/ncidod/dvrd/vcjd/index.htm. Accessed 1/28/2009.
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Basic Information

  • You can obtain information on this topic from the Centers for Disease Control and Prevention (CDC). The CDC is recognized as the lead federal agency for developing and applying disease prevention and control, environmental health, and health promotion and education activities designed to improve the health of the people of the United States.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it┬áprovides more information about this topic.
  • The National Endocrine and Metabolic Diseases Information Service, a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), provides information on this topic. Click on the link to view the information on this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
  • The World Health Organization (WHO) produces guidelines and standards, helps countries to address public health issues, and supports and promotes health research. The WHO has developed a fact sheet on this condition. To view the fact sheet, click on the link.

In Depth Information

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  • PubMed is a searchable database of medical literature and lists journal articles that discuss Variant Creutzfeldt-Jakob disease. Click on the link to view a sample search on this topic.

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Other Names for this Disease
  • New variant of CJD
  • Nv-CJD
  • Variant CJD
  • Variant Creutzfeldt-Jacob disease
  • VCJD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.