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Genetic and Rare Diseases Information Center (GARD)

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Multicentric Castleman’s Disease

Other Names for this Disease
  • Idiopathic multicentric Castleman's disease
  • MCD
  • Multicentric plasma cell variant of Castleman's disease
  • Plasmablastic multicentric Castleman disease
  • PMCD
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Your Question

How might multicentric Castleman's disease be treated?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is multicentric Castleman's disease?

Multicentric Castleman’s disease is a type of Castleman's disease that affects more than a single group of lymph nodes. It can also affect other organs containing lymphoid tissue. People with multicentric Castleman's disease often have serious infections, fevers, weight loss, fatigue, night sweats, and nerve damage that can cause weakness and numbness. Blood tests may indicate anemia and high levels of antibodies in the blood (hypergammaglobulinemia). They may also experience loss of appetite, nausea, vomiting, and enlarged liver and spleen. Multicentric Castleman disease can weaken the immune system, making it hard to fight infection. Infections in people with multicentric Castleman's disease can be very serious and may even be fatal. Multicentric Castleman's disease acts very much like lymphoma. In fact, about 20% of people with this disease eventually develop lymphoma. Treatment may involve surgery, chemotherapy or radiation therapy.[1][2] 
Last updated: 8/18/2011

How might multicentric Castleman's disease be treated?

Treatment of multicentric Castleman's disease may be difficult. No single treatment works for all patients. Surgery is used for the diagnosis, but the disease is often too widespread to remove it all with surgery. Occasionally, removal of just some of the diseased tissue appears to help. Since several types of treatment have been used with success in some patient populations, doctors often try one or a combination of treatment modalities in an attempt to put the disease in remission. Corticosteroids, chemotherapy, radiation, and immune therapy are often used. Unfortunately, while treatment may help, the disease often comes back. If lymphoma develops, it usually grows fast and is difficult to treat.[1]

More detailed information about the treatment of multicentric Castleman's disease can be accessed by clicking here.
Last updated: 4/5/2011