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Genetic and Rare Diseases Information Center (GARD)

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Multicentric Castleman’s Disease

Other Names for this Disease
  • Idiopathic multicentric Castleman's disease
  • MCD
  • Multicentric plasma cell variant of Castleman's disease
  • Plasmablastic multicentric Castleman disease
  • PMCD
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Your Question

Does the multicentric form of Castleman's disease always cause symptoms?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What are the signs and symptoms of multicentric Castleman's disease?

People with multicentric Castleman's disease usually develop systemic signs and symptoms.[1] These may include serious infections, fevers, weight loss, weakness and fatigue from anemia, enlarged peripheral lymph nodes (particularly around the neck, collarbone, under the arm and in the groin), night sweats, and nerve damage that can lead to weakness and numbness in the hands and feet (peripheral neuropathy). They may also experience loss of appetite, nausea, vomiting, and enlarged liver and spleen. Multicentric Castleman's disease can weaken the immune system, making it hard to fight infection. Infections in people with this condition can be very serious and may even be fatal. Multicentric Castleman's disease also increases the risk of developing lymphoma, a cancer of lymphoid tissue.[2][1] 
Last updated: 8/18/2011

Does multicentric Castleman's disease always cause symptoms?

While most sources indicate that systemic symptoms are usually (or often) present [2][1], at least one states that multicentric forms of Castleman's disease are always symptomatic.[3]  
Last updated: 8/18/2011