Other Names for this Disease
- Acute lipodermatosclerosis
- Hypodermitis sclerodermaformis
- Sclerosing panniculitis
Your QuestionPlease send me any information you have regarding lipodermatosclerosis. The physicians in my area do not know how to treat my condition. The pain is getting unbearable at times and I am looking for any kind of treatments that may help my condition.
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Questions on this page
Acute lipodermatosclerosis generally occurs without any preceding illness or local injury. It presents as episodes of painful inflammation in the inner leg above the ankle, resembling cellulitis. The affected area is red, tender and warm, and may be scaly. Some thickening of the skin can be felt but this is not sharply demarcated as in chronic lipodermatosclerosis. Patients with acute lipodermatosclerosis are mainly middle-aged.
Chronic lipodermatosclerosis may follow an acute episode or develop gradually. Common findings in chronic lipodermatosclerosis include pain, hardening of the skin, localized thickening, moderate redness, increased pigmentation, small white scarred areas (atrophie blanche), increased fluid in the leg (edema), varicose veins, and leg ulcers. Chronic lipodermatosclerosis also predisposes to venous or stasis eczema.
- Vein surgery, endovenous laser ablation or sclerotherapy
- Weight reduction
- Ultrasound therapy
- Fibrinolytic agents such as stanozolol
- Pentoxyfylline to increase blood flow
- Clobetasol propionate (ultrapotent topical steroid) or intralesional triamcinolone injections to reduce inflammation
- Capsaicin to reduce pain
You can also contact the Patient Recruitment and Public Liaison (PRPL) Office at the National Institutes of Health (NIH) at 800-411-1222 to speak with a specialist, who can help you determine if you are eligible for any clinical trials.
Resources on many charitable or special-fare flights to research and treatment sites and low-cost hospitality accommodations for outpatients and family members, as well as ambulance services, are listed on the Web site of the Office of Rare Diseases (ORD), part of the National Institutes of Health.
- Bruce AJ. et al. Lipodermatosclerosis: Review of cases evaluated at Mayo Clinic. J Am Acad Dermatol. 2002;
- Ginsburg PM, Ehrenpreis ED. NORD Guide to Rare Disorders. Philadelphia PA: Lippincott Williams & Wilkins; 2003;
- Phelps RG, Shoji T. The Mount Sinai Journal of Medicine. 2001; http://www.mssm.edu/msjournal/68/v68_pages262_267.pdf. Accessed 2/13/2008.
- Duffill M. Lipodermatosclerosis. DermNet. June 2011; http://www.dermnetnz.org/vascular/lipodermatosclerosis.html. Accessed 7/21/2011.
- Fischer DR, Matthews JB. Diseases of the mesentery and omentum. In: Feldman M, Friedman LS, Brandt LJ. eds. Sleisenger & Fordtran’s Gastrointestinal and Liver Disease, 7th ed . Philadelphia, PA: Saunders, an imprint of Elsevier Inc.; 2002;
- Habif TP. Stasis dermatitis and venous ulceration: Postphlebitic syndromes. Habif: Clinical Dermatology, 4th ed. New York, NY: Mosby, Inc; 2004;
- Camilleri MJ, Danil Su WP. Panniculitis. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, eds. Fitzpatrick’s Dermatology in General Medicine, 6th ed. New York, NY: McGraw-Hill; 2003;