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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Lattice corneal dystrophy type 1


Other Names for this Disease
  • CDL1
  • Corneal dystrophy, lattice type 1
  • LCD1
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


Your Question

I have lattice corneal dystrophy and have had light sensitivity and astigmatism for a number of years. Over the past 18 months my vision has become much worse.  Is any current research going on that relates to lattice corneal dystrophy.  Also, have there been any recent articles published in medical journals about this disease? Since there are no other cases of corneal dystrophy in my family, yet this is a genetic disease, I'm interested in finding out more about genetic testing.  

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Are there any research studies enrolling people with lattice corneal dystrophy?

Yes. The U.S. National Institutes of Health, through the National Library of Medicine, developed ClinicalTrials.gov to provide patients, family members, and members of the public with current information on clinical research studies. Currently, 8 clinical trials are identified as enrolling individuals with hereditary corneal dystrophies. To find these trials, click on the link above and use 'corneal dystrophy' as your search term. After you click on a study, review its 'eligibility' criteria to determine its appropriateness. Use the study’s contact information to learn more. Check this site often for regular updates.

In addition,  ClinicalTrials.gov lists studies titled Potential Research Participants for Future Studies of Inherited Eye Diseases, Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases and Screening for Studies on Inherited Eye Diseases which may be of interest to you. To find these trials, click on the links above.

You can also contact the Patient Recruitment and Public Liaison (PRPL) Office at the National Institutes of Health (NIH). We recommend calling the toll-free number listed below to speak with a specialist, who can help you determine if you are eligible for any clinical trials.  

Patient Recruitment and Public Liaison Office
NIH Clinical Center
Bethesda, Maryland 20892-2655
Toll-free: 800-411-1222
Fax: 301-480-9793
Email: prpl@mail.cc.nih.gov
Web site:  http://clinicalcenter.nih.gov/

If you are interested in enrolling in a clinical trial, you can find helpful general information on clinical trials at the following ClinicalTrials.gov Web page.
http://clinicaltrials.gov/ct2/info/understand

A tutorial about clinical trials that can also help answer your questions can be found at the following link from the National Library of Medicine:
http://www.nlm.nih.gov/medlineplus/tutorials/cancerclinicaltrials/htm/lesson.htm

Resources on many charitable or special-fare flights to research and treatment sites and low-cost hospitality accommodations for outpatients and family members, as well as ambulance services, are listed on the Web site of the Office of Rare Diseases (ORD), part of the National Institutes of Health.
http://rarediseases.info.nih.gov/Resources.aspx?PageID=8

CRISP (Computer Retrieval of Information on Scientific Projects) is a searchable database of federally funded biomedical research projects conducted at universities, hospitals, and other research institutions. Currently, 1 project listed on CRISP involves lattice corneal dystrophy. Although this project may not conduct studies on humans, you may want to contact the investigator to learn more. To read about this study, click on the link below. In the 'enter search terms' box, enter 'lattice corneal dystrophy' and click the 'and' button below the box. Then click 'Submit Query.'
http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen

Last updated: 6/13/2008

How can I find recent journal articles on lattice corneal dystrophy?

You can find relevant journal articles on lattice corneal dystrophy through a service called PubMed, a searchable database of medical literature. Information on finding an article and its title, authors, and publishing details is listed here.  Some articles are available as a complete document, while information on other studies is available as a summary abstract.  To obtain the full article, contact a medical/university library (or your local library for interlibrary loan), or order it online using the following link. Using 'lattice corneal dystrophy' as your search term should locate articles. To narrow your search, click on the “Limits” tab under the search box and specify your criteria for locating more relevant articles.  Click here to view a search of articles on lattice corneal dystrophy published within the last year.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed

The National Library of Medicine (NLM) Web site has a page for locating libraries in your area that can provide direct access to these journals (print or online). The Web page also describes how you can get these articles through interlibrary loan and Loansome Doc (an NLM document-ordering service). You can access this page at the following link http://nnlm.gov/members/. You can also contact the NLM toll-free at 888-346-3656 to locate libraries in your area.

Last updated: 6/13/2008

Can a person with no family history of lattice corneal dystrophy still develop it?

Yes. Autosomal dominant and autosomal recessive inheritance have been reported in people with lattice corneal dystrophy. These are two of several ways that a disorder can be passed down through families. If a disease is autosomal dominant, it means a person only needs to get the abnormal gene from one parent in order to inherit the disease. The mutation may come from an affected parent or could occur randomly for the first time in either the mother’s egg or father’s sperm.[1] Mutations that occur only in an egg or sperm cell, or those that occur just after fertilization, are called new (de novo) mutations. De novo mutations may explain how some individuals with a genetic disorder have no family history.[2]

An autosomal recessive disorder means two copies of an abnormal gene must be present in order for the disease or trait to develop. A person with only one gene mutation would not have the disease. These individuals are said to be "carriers." A child with an autosomal recessive disease inherits two copies of a gene mutation, one from each carrier parent. The chance that a sibling would also be affected is 25%.[3] Click here to read more about gene mutations and how they can occur.

Last updated: 6/13/2008

Is genetic testing available for lattice corneal dystrophy?

Yes. GeneTests lists the names of laboratories that are performing genetic testing for lattice corneal dystrophy. Most of the laboratories listed through GeneTests do not accept direct contact from patients and their families; therefore, if you are interested in learning more, you will need to work with a health care provider or a genetics professional. To view the contact information for the clinical laboratories, conducting testing for lattice dystrophy type 1 and 3a click here. To access the contact information for the research laboratories performing genetic testing for lattice dystrophy type 3 click here
Last updated: 6/13/2008

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