Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Nephrogenic Systemic Fibrosis


Other Names for this Disease
  • Nephrogenic Fibrosing Dermopathy
  • NFD
  • NSF
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview


Nephrogenic systemic fibrosis is a condition that affects different parts of the body, particularly the skin. Symptoms of the condition may include progressive swelling and tightening of the skin, sometimes resulting in contractures, and pruritis (itching).  The skin findings are similar to those seen in patients with scleroderma.  Nephrogenic systemic fibrosis was first described in 1997.[1] Being exposed to gadolinium-containing contrast agents during MRI testing has been identified as a significant risk factor for development of this disease.[2]
Last updated: 4/24/2013

References

  1. Sweeney S, Cropley TG. Cutaneous Changes in Renal Disorders. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, eds. Fitzpatrick's Dermatology in General Medicine. Vol 2. 6th ed. United States: The McGraw-Hill Companies, Inc.; 2003: 1623..
  2. Nephrogenic systemic fibrosis. Mayo Foundation for Medical Education and Research. http://www.mayoclinic.org/nephrogenic-systemic-fibrosis/. Accessed 4/24/2013.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

Please contact us with your questions about Nephrogenic Systemic Fibrosis. We will answer your question and update these pages with new resources and information.

Basic Information

  • The International Scleroderma Network (ISN) provides information on nephrogenic fibrosing dermopathy since the skin symptoms of NFD are scleroderma-like.  Click on the ISN link to view the information.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Nephrogenic Systemic Fibrosis. Click on the link to view a sample search on this topic.

Insurance Issues