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Leukonychia totalis

Other Names for this Disease
  • Hereditary white nails
  • Nail disorder, nonsyndromic congenital, 3
  • NDNC3
  • Porcelain nails
  • Total leukonychia
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Leukonychia totalis is a nail condition characterized by complete whitening of the entire nail plate.[1] It is usually inherited in an autosomal dominant manner. Less commonly, it may be inherited in an autosomal recessive manner, or acquired (not inherited) during a person's lifetime.[2] The inherited forms can be caused by mutations in the PLCD1 gene and generally involve the entire plate of all 20 nails.[3][1] In some cases, leukonychia totalis has been associated with various other abnormalities or syndromes. Treatment may focus on the underlying cause when it is associated with another condition.[1]
Last updated: 2/18/2014


  1. Howard SR, Siegfried EC. A case of leukonychia. J Pediatr. September, 2013; 163(3):914-915. Accessed 2/18/2014.
  2. Yalçin Tüzün, Özge Karakus. Leukonychia. J Turk Acad Dermatol. 2009; 3(1):Accessed 2/18/2014.
  3. Marla J. F. O'Neill. NAIL DISORDER, NONSYNDROMIC CONGENITAL, 3; NDNC3. OMIM. August 11, 2011; Accessed 2/18/2014.
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In Depth Information

  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Leukonychia totalis. Click on the link to view a sample search on this topic.