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Other Names for this Disease
- Dowling-Degos Kitamura disease
- Kitamura reticulate acropigmentation
- Reticular pigment anomaly of flexures
- Reticulate acropigmentation of Kitamura
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pilar cysts) on the scalp, and rarely, patches of skin that are unusually light in color (hypopigmented). Symptoms typically develop in late childhood or in adolescence and progress over time. While the skin changes caused by Dowling-Degos disease can be bothersome, they typically don't cause health problems. Dowling-Degos disease is caused by mutations in the KRT5 gene. This condition is inherited in an autosomal dominant pattern.Dowling-Degos disease is a skin condition characterized by a lacy or net-like (reticulate) pattern of abnormally dark skin coloring (hyperpigmentation), particularly in the body's folds and creases. Other features may include dark lesions on the face and back that resemble blackheads, red bumps around the mouth that resemble acne, depressed or pitted scars on the face similar to acne scars but with no history of acne, cysts within hair follicles (
Last updated: 2/4/2013
- Dowling-Degos disease. Genetics Home Reference (GHR). November 2012; http://ghr.nlm.nih.gov/condition/dowling-degos-disease. Accessed 2/4/2013.
- Genetics Home Reference (GHR) contains information on Dowling-Degos disease. This website is maintained by the National Library of Medicine.
In Depth Information
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Dowling-Degos disease. Click on the link to go to OMIM and review these resources.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Dowling-Degos disease. Click on the link to view a sample search on this topic.