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Large granular lymphocyte leukemia

Other Names for this Disease
  • LGL leukemia
  • T-cell large granular lymphocyte leukemia
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Large granular lymphocyte (LGL) leukemia is a rare cancer of a type of white blood cells called lymphocytes. LGL leukemia causes a slow increase in white blood cells called T lymphocytes, or T cells, which originate in the lymph system and bone marrow and help to fight infection. This disease usually affects people in their sixties. Symptoms include anemia; low levels of platelets (thrombocytopenia) and infection-fighting neutrophils (neutropenia) in the blood; and an enlarged spleen. About one-third of patients are asymptomatic at the time of diagnosis. The exact cause of LGL leukemia is unknown. Doctors can diagnose this disease through a bone marrow biopsy, or by using a specialized technique in which various types of blood or bone marrow cells are separated, identified, and counted.[1]
Last updated: 8/2/2011


  1. T-cell large granular lymphocyte leukemia. Orphanet. May 2007; Accessed 8/2/2011.
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  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Large granular lymphocyte leukemia. Click on the link to view a sample search on this topic.