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Other Names for this Disease
- Encephalopathy of childhood
- Epileptic encephalopathy Lennox-Gastaut type
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 This condition can be caused by brain malformations, perinatal asphyxia (lack of oxygen), severe head injury, central nervous system infection and inherited degenerative or metabolic conditions. In about one-third of cases, no cause can be found. Treatment for Lennox-Gastaut syndrome includes anti-epileptic medications such as valproate, lamotrigine, felbamate, or topiramate. There is usually no single antiepileptic medication that will control seizures. Children may improve initially, but many later show tolerance to a drug or develop uncontrollable seizures.Lennox-Gastaut syndrome is a form of severe epilepsy that begins in childhood. It is characterized by multiple types of seizures and intellectual disability.
Last updated: 9/17/2013
- Lennox-Gastaut syndrome. Genetics Home Reference (GHR). July 2010; http://ghr.nlm.nih.gov/condition/lennox-gastaut-syndrome. Accessed 9/17/2013.
- NINDS Lennox-Gastaut Syndrome Information Page. National Institute of Neurological Disorders and Stroke (NINDS). July 31, 2013; http://www.ninds.nih.gov/disorders/lennoxgastautsyndrome/lennoxgastautsyndrome.htm. Accessed 9/17/2013.
- Genetics Home Reference (GHR) contains information on Lennox-Gastaut syndrome. This website is maintained by the National Library of Medicine.
- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
In Depth Information
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Lennox-Gastaut syndrome. Click on the link to go to OMIM and review these resources.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Lennox-Gastaut syndrome. Click on the link to view a sample search on this topic.