Print friendly version
Brown-Vialetto-Van Laere syndrome
Other Names for this Disease
- Pontobulbar palsy and neurosensory deafness
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
Brown-Vialetto-Van Laere syndrome (BVVL) is a type of degenerative nerve disease. Initial symptoms occur in infancy to early adulthood and progress with time. The rate of progression can vary from person to person. The syndrome is generally characterized by sensorineural deafness, paralysis of the cranial nerves, and lower and upper motor neuron disease. Signs and symptoms may include vocal cord paralysis, drooping eyelids, facial weakness, slurred speech, difficulty swallowing, diminishing eye sight, neck and shoulder weakness, weakness in the arms and legs, autonomic dysfunction, and difficulty breathing. The cause of the syndrome is currently unknown and treatment is supportive. Both genetic and sporadic cases have been reported in the medical literature.
- Genetics Home Reference (GHR) contains information on Brown-Vialetto-Van Laere syndrome. Click on the link to go to GHR and review the information.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge. Click on the link to read information on this topic.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Brown-Vialetto-Van Laere syndrome. Click on the link to view a sample search on this topic.
- The The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Brown-Vialetto-Van Laere syndrome. Click on the link to go to OMIM and review these resources.
Selected Full-Text Journal Articles
- Sathasivam S. Brown-Vialetto-Van Laere syndrome. Orphanet Journal of Rare Diseases. 2008, April 17;3:9.