{"Name":"Aggressive NK-cell leukemia","DiseaseID__c":"GARD:0010493","id":10493,"encodedName":"aggressive-nk-cell-leukemia","IsDeleted":false,"Disease_Name_Full__c":"Aggressive NK-cell leukemia","Xref_IDs__c":"128833001; 721310007; C1292777; C8647; DOID:1035; MEDGEN:266235; MONDO:0019470; ORPHA:86873","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0019470","Disease_Description__c":"A rare, highly aggressive, Epstein-Barr virus-associated leukemia, also known as aggressive NK-cell leukemia/lymphoma; it may represent the leukemic counterpart of nasal type extranodal NK/T-cell lymphomas. It affects primarily teenagers and young adults. It is characterized by the systemic proliferation of NK cells in the peripheral blood, bone marrow, liver, and spleen.","GARD_Name__c":"Aggressive NK-cell leukemia","GARD_Synonym__c":"aggressive natural killer-cell leukemia; aggressive nk cell leukemia; aggressive nk-cell leukaemia (morphologic abnormality); aggressive nk-cell leukemia (morphologic abnormality); aggressive nk-cell leukemia/lymphoma; aggressive nk-cell lymphoma; ankcl; large granular lymphocyte leukemia, nk-cell type; leukaemia (disease) of natural killer cell; leukemia (disease) of natural killer cell; natural killer cell leukaemia; natural killer cell leukaemia (disease); natural killer cell leukemia; natural killer cell leukemia (disease); nk cell leukaemia; nk cell leukemia; nk-cell large granular lymphocyte leukaemia; nk-cell large granular lymphocyte leukemia; nk-cell leukaemia; nk-cell leukemia; nk-cell lgl leukaemia; nk-cell lgl leukemia","Curated_Disease_Description_Source__c":"MONDO:0019470","Curated_Disease_Description__c":"A rare, highly aggressive, Epstein-Barr virus-associated leukemia, also known as aggressive NK-cell leukemia/lymphoma; it may represent the leukemic counterpart of nasal type extranodal NK/T-cell lymphomas. It affects primarily teenagers and young adults. It is characterized by the systemic proliferation of NK cells in the peripheral blood, bone marrow, liver, and spleen.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:86873","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0019470","ORPHANET_ID__c":"ORPHA:86873","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Leucemia agresiva de células nk","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"leucemia agresiva de células nk","Spanish_GARD_Synonym__c":"ankcl; leucemia lgl de células nk; leucemia linfocítica granular de células nk grandes; linfoma agresivo de células nk","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A rare, highly aggressive, Epstein-Barr virus-associated leukemia, also known as aggressive NK-cell leukemia/lymphoma; it may represent the leukemic counterpart of nasal type extranodal NK/T-cell lymphomas. It affects primarily teenagers and young adults. It is characterized by the systemic proliferation of NK cells in the peripheral blood, bone marrow, liver, and spleen.","Curated_Disease_Description_Source__c":"MONDO:0019470","GARD_Synonym__c":"aggressive natural killer-cell leukemia; aggressive nk cell leukemia; aggressive nk-cell leukaemia (morphologic abnormality); aggressive nk-cell leukemia (morphologic abnormality); aggressive nk-cell leukemia/lymphoma; aggressive nk-cell lymphoma; ankcl; large granular lymphocyte leukemia, nk-cell type; leukaemia (disease) of natural killer cell; leukemia (disease) of natural killer cell; natural killer cell leukaemia; natural killer cell leukaemia (disease); natural killer cell leukemia; natural killer cell leukemia (disease); nk cell leukaemia; nk cell leukemia; nk-cell large granular lymphocyte leukaemia; nk-cell large granular lymphocyte leukemia; nk-cell leukaemia; nk-cell leukemia; nk-cell lgl leukaemia; nk-cell lgl leukemia","Name":"Aggressive NK-cell leukemia","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Blood Cancer United","Website__c":"https://bloodcancerunited.org/"},{"Account_Name__c":"University of Virginia LGL Leukemia Program","Website__c":"https://uvahealth.com/services/lgl-leukemia-program"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Hematology","Tag_Category__c":"Disease Category;Specialist","category_description":"Blood diseases affect the blood or blood-forming organs, including red blood cells, white blood cells, platelets, plasma, and bone marrow.","curated_tag_name":"Blood diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:86873"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.orpha.net/en/disease/detail/86873","Source__c":"C1292777; MONDO:0019470; ORPHA:86873","Xref__c":"ORPHA:86873"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A1035","Source__c":"MONDO:0019470","Xref__c":"DOID:1035"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C8647","Source__c":"C1292777; MONDO:0019470","Xref__c":"C8647"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=721310007","Source__c":"C1292777; MONDO:0019470","Xref__c":"721310007"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1292777","Source__c":"C1292777","Xref__c":"C1292777"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=266235","Source__c":"C1292777","Xref__c":"MEDGEN:266235"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019470","Source__c":"GARD:0010493","Xref__c":"MONDO:0019470"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=128833001","Source__c":"C1292777","Xref__c":"128833001"}],"Inheritance__c":["Non-Mendelian inheritance"],"tags":{"Specialist":["Cancer - Oncologist","Hematology"],"Disease Category":["Cancer","Hematology"]},"synonyms":["aggressive natural killer-cell leukemia"," aggressive nk cell leukemia"," aggressive nk-cell leukaemia (morphologic abnormality)"," aggressive nk-cell leukemia (morphologic abnormality)"," aggressive nk-cell leukemia/lymphoma"," aggressive nk-cell lymphoma"," ankcl"," large granular lymphocyte leukemia, nk-cell type"," leukaemia (disease) of natural killer cell"," leukemia (disease) of natural killer cell"," natural killer cell leukaemia"," natural killer cell leukaemia (disease)"," natural killer cell leukemia"," natural killer cell leukemia (disease)"," nk cell leukaemia"," nk cell leukemia"," nk-cell large granular lymphocyte leukaemia"," nk-cell large granular lymphocyte leukemia"," nk-cell leukaemia"," nk-cell leukemia"," nk-cell lgl leukaemia"," nk-cell lgl leukemia"]}