{"Name":"Meconium aspiration syndrome","DiseaseID__c":"GARD:0010494","id":10494,"encodedName":"meconium-aspiration-syndrome","IsDeleted":false,"Disease_Name_Full__c":"Meconium aspiration syndrome","Xref_IDs__c":"206292002; C0025048; C87093; D008471; DOID:11049; MEDGEN:6258; MONDO:0006851; ORPHA:70588; P24.0","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":2,"Description_Source__c":"MONDO:0006851","Disease_Description__c":"A serious condition in which a newborn breathes a mixture of meconium (the first intestinal discharge) and amniotic fluid into the lungs around the time of delivery. Meconium aspiration syndrome occurs in 5-10 percent of births and typically occurs when the infant is stressed, as when the infant is past its due date.","GARD_Name__c":"Meconium aspiration syndrome","GARD_Synonym__c":"mas; mas - meconium aspiration syndrome; meconium aspiration; neonatal aspiration of meconium","Curated_Disease_Description_Source__c":"GARD:0010494","Curated_Disease_Description__c":"Meconium aspiration syndrome is a serious condition in which a newborn breathes a mixture of meconium and amniotic fluid into the lungs around the time of delivery. This can cause breathing difficulties due to swelling (inflammation) in the baby's lungs after birth.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"as a Newborn and as an Infant","SourceID__c":"ORPHA:70588","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0006851","ORPHANET_ID__c":"ORPHA:70588","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Síndrome de aspiración de meconio","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"síndrome de aspiración de meconio","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:97955","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Meconium aspiration syndrome is a serious condition in which a newborn breathes a mixture of meconium and amniotic fluid into the lungs around the time of delivery. This can cause breathing difficulties due to swelling (inflammation) in the baby's lungs after birth.","Curated_Disease_Description_Source__c":"GARD:0010494","GARD_Synonym__c":"mas; mas - meconium aspiration syndrome; meconium aspiration; neonatal aspiration of meconium","Name":"Meconium aspiration syndrome","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Children's Interstitial Lung Disease Foundation","Website__c":"https://child-foundation.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Pulmonology","Tag_Category__c":"Disease Category;Specialist","category_description":"Respiratory diseases affect the nose, mouth, throat, voice box, windpipe, lungs, or blood vessels.","curated_tag_name":"Respiratory diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Infancy","Provided_By__c":"ORPHA:70588"},{"Age_At_Onset__c":"Neonatal","Provided_By__c":"ORPHA:70588"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A11049","Source__c":"MONDO:0006851","Xref__c":"DOID:11049"},{"URL__c":"https://www.orpha.net/en/disease/detail/70588","Source__c":"C0025048; MONDO:0006851; ORPHA:70588","Xref__c":"ORPHA:70588"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0025048","Source__c":"C0025048","Xref__c":"C0025048"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C87093","Source__c":"C0025048; MONDO:0006851","Xref__c":"C87093"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=6258","Source__c":"C0025048","Xref__c":"MEDGEN:6258"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C008471","Source__c":"C0025048; MONDO:0006851","Xref__c":"D008471"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=206292002","Source__c":"C0025048; MONDO:0006851","Xref__c":"206292002"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0006851","Source__c":"GARD:0010494","Xref__c":"MONDO:0006851"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/P24.0","Source__c":"MONDO:0006851","Xref__c":"P24.0"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Respiratory distress is objectively observable as the physical or emotional consequences from the experience of dyspnea. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002098","HPO_Synonym__c":"Breathing difficulties; Labored breathing; Respiratory difficulties","HPO_Name__c":"Respiratory distress","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Respiratory failure in the newborn.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012768","HPO_Synonym__c":"Asphyxia neonatorum","HPO_Name__c":"Neonatal asphyxia","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"This term groups terms representing abnormal findings derived from chest X-ray investigation of the lung. In general, lung abnormalities can manifest as opacities (areas of increased density) or as regions with decreased density.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031983","HPO_Synonym__c":"Abnormal chest radiograph finding (lung)","HPO_Name__c":"Abnormal pulmonary thoracic imaging finding","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Imaging_CT"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"The presence of free air in the mediastinum.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0025421","HPO_Name__c":"Pneumomediastinum","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Premature rupture of membranes (PROM) is a condition which occurs in pregnancy when the amniotic sac ruptures more than an hour before the onset of labor.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001788","HPO_Name__c":"Premature rupture of membranes","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Pulmonary hypertension is defined mean pulmonary artery pressure of 25mmHg or more and pulmonary capillary wedge pressure of 15mmHg or less when measured by right heart catheterisation at rest and in a supine position.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002092","HPO_Synonym__c":"Increased blood pressure in blood vessels of lungs; Pulmonary artery hypertension","HPO_Name__c":"Pulmonary arterial hypertension","Feature_System__c":"Cardiovascular System; Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"Encephalopathy is a term that means brain disease, damage, or malfunction. In general, encephalopathy is manifested by an altered mental state.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001298","HPO_Name__c":"Encephalopathy","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Any abnormality in the variability of the time interval between successive heartbeats.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031860","HPO_Name__c":"Abnormal heart rate variability","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Delivery of a fetus through surgical incisions made through the abdominal wall (laparotomy) and the uterine wall (hysterotomy).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0011410","HPO_Synonym__c":"Caesarean section","HPO_Name__c":"Caesarean section","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Pneumonia due to the aspiration (breathing in) of food, liquid, or gastric contents into the upper respiratory tract.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0011951","HPO_Name__c":"Aspiration pneumonia","Feature_System__c":"Respiratory system; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An abnormally low level of blood oxygen.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012418","HPO_Synonym__c":"Low blood oxygen level","HPO_Name__c":"Hypoxemia","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"A pregnancy that extends to 42 weeks of gestation or beyond.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031169","HPO_Name__c":"Postterm pregnancy","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Amniotic fluid containing the earliest stools of a mammalian infant.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012420","HPO_Synonym__c":"Meconium staining of amniotic fluid; Meconium-stained amniotic fluid","HPO_Name__c":"Meconium stained amniotic fluid","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An intrauterine state characterized by suboptimal values in the fetal heart rate, oxygenation of fetal blood, or other parameters indicative of compromise of the fetus. Signs of fetal distress include repetitive variable decelerations, fetal tachycardia or bradycardia, late decelerations, or low biophysical profile.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0025116","HPO_Name__c":"Fetal distress","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Collapse of part of a lung associated with absence of inflation (air) of that part.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100750","HPO_Synonym__c":"Partial or complete collapse of part or entire lung; Pulmonary atelectasis","HPO_Name__c":"Atelectasis","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Imaging_CT"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"The retrograde (backwards) flow of blood through the pulmonary valve into the right ventricle during diastole.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0010444","HPO_Synonym__c":"Pulmonary incompetence; Pulmonary valve insufficiency; Pulmonary valve regurgitation; Puolmonary valve insufficiency","HPO_Name__c":"Pulmonic regurgitation","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0005828","HPO_Name__c":"Transient pulmonary infiltrates","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Imaging_CT"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Accumulation of air in the pleural cavity leading to a partially or completely collapsed lung.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002107","HPO_Synonym__c":"Collapsed lung","HPO_Name__c":"Pneumothorax","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A high-pitched whistling sound associated with labored breathing.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0030828","HPO_Synonym__c":"Wheezing","HPO_Name__c":"Wheezing","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:70588","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001511","HPO_Synonym__c":"Fetal growth restriction; FGR; In utero growth retardation; Intrauterine growth failure; Intrauterine growth restriction; Intrauterine growth retardation, IUGR; Intrauterine retardation; IUGR; Prenatal growth deficiency; Prenatal growth failure; Prenatal growth retardation; Prenatal onset growth retardation; Prenatal-onset growth retardation; Small for gestational age infant","HPO_Name__c":"Intrauterine growth retardation","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Disease Category":["Pulmonology"],"Specialist":["Pulmonology","Pediatrics"]},"synonyms":["mas"," mas - meconium aspiration syndrome"," meconium aspiration"," neonatal aspiration of meconium"]}