{"Name":"Astroblastoma","DiseaseID__c":"GARD:0010635","id":10635,"encodedName":"astroblastoma","IsDeleted":false,"Disease_Name_Full__c":"Astroblastoma","Xref_IDs__c":"48952003; C0334587; C4324; DOID:7305; MEDGEN:90811; MONDO:0016707; ORPHA:251679","USA_Estimate__c":"1,000","No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"1 to 8,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":4,"Description_Source__c":"MONDO:0016707","Disease_Description__c":"A very rare glial neoplasm of the central nervous system, most often with an intra-axial peripheral supratentorial location in one hemisphere of the frontal or parietal lobes and usually presenting in infants and young adults with symptoms of vomiting, loss of consciousness, epileptic seizures and headaches.","GARD_Name__c":"Astroblastoma","GARD_Synonym__c":"astroblastoma (morphologic abnormality)","Curated_Disease_Description_Source__c":"GARD:0010635","Curated_Disease_Description__c":"Astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. It can occur in individuals of any age, but occurs predominantly in children and young adults. Signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. Because these tumors are rare, there is little known regarding their behavior and how they should be managed. Adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial).","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"1,000","Age_at_Onset_Snippet_Text__c":"at a variety of ages","SourceID__c":"ORPHA:251679","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0016707","ORPHANET_ID__c":"ORPHA:251679","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Astroblastoma","Spanish_Description_Source__c":"ORPHA:251679","Spanish_Description__c":"Es una neoplasia glial extremadamente infrecuente del sistema nervioso central. Se da con mayor frecuencia con una localización supratentorial periférica intra-axial en un hemisferio de los lóbulos frontales o parietales y suele presentarse en niños y jóvenes adultos con síntomas de vómitos, pérdida de conciencia, crisis epilépticas y dolores de cabeza.","Spanish_Disease_Name__c":"astroblastoma","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. It can occur in individuals of any age, but occurs predominantly in children and young adults. Signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. Because these tumors are rare, there is little known regarding their behavior and how they should be managed. Adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial).","Curated_Disease_Description_Source__c":"GARD:0010635","GARD_Synonym__c":"astroblastoma (morphologic abnormality)","Name":"Astroblastoma","Curated_USA_Estimate__c":"1,000","estimateUsa":"1,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"American Brain Tumor Association","Website__c":"https://www.abta.org/"},{"Account_Name__c":"National Brain Tumor Society","Website__c":"https://braintumor.org/"},{"Account_Name__c":"Pediatric Brain Tumor Foundation","Website__c":"https://www.curethekids.org/"},{"Account_Name__c":"Children's Brain Tumor Foundation","Website__c":"https://cbtf.org/"},{"Account_Name__c":"International Brain Tumour Alliance","Website__c":"https://theibta.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Childhood","Provided_By__c":"ORPHA:251679"},{"Age_At_Onset__c":"Infancy","Provided_By__c":"ORPHA:251679"},{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:251679"},{"Age_At_Onset__c":"Adolescent","Provided_By__c":"ORPHA:251679"}],"External_Identifier_Disease__c":[{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4324","Source__c":"C0334587; MONDO:0016707","Xref__c":"C4324"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0334587","Source__c":"C0334587","Xref__c":"C0334587"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=90811","Source__c":"C0334587","Xref__c":"MEDGEN:90811"},{"URL__c":"https://www.orpha.net/en/disease/detail/251679","Source__c":"C0334587; MONDO:0016707; ORPHA:251679","Xref__c":"ORPHA:251679"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A7305","Source__c":"MONDO:0016707","Xref__c":"DOID:7305"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=48952003","Source__c":"C0334587","Xref__c":"48952003"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0016707","Source__c":"GARD:0010635","Xref__c":"MONDO:0016707"}],"tags":{"Specialist":["Cancer - Oncologist","Neurology","Pediatrics"],"Disease Category":["Cancer","Neurology"]},"synonyms":["astroblastoma (morphologic abnormality)"]}