{"Name":"Anaplastic ganglioglioma","DiseaseID__c":"GARD:0010639","id":10639,"encodedName":"anaplastic-ganglioglioma","IsDeleted":false,"Disease_Name_Full__c":"Anaplastic ganglioglioma","Xref_IDs__c":"1157071000; C0431112; C4717; MEDGEN:140906; MONDO:0016734; ORPHA:251957","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":3,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0016734","Disease_Description__c":"A WHO grade III neuroepithelial neoplasm composed of neoplastic, mature ganglion cells and anaplastic glial cells. The anaplastic changes in the glial component and high MIB-1 and TP53 labeling indices may indicate aggressive behavior. However, the correlation of histological anaplasia with clinical outcome is inconsistent. (Adapted from WHO)","GARD_Name__c":"Anaplastic ganglioglioma","GARD_Synonym__c":"ganglioglioma, anaplastic","Curated_Disease_Description_Source__c":"GARD:0010639","Curated_Disease_Description__c":"Anaplastic ganglioglioma (AGG) is a very rare type of brain tumor that is a type of ganglioglioma. In general, gangliogliomas are classified as grade I or low grade tumors, meaning that they grow slowly and are considered benign. Anaplastic gangliogliomas, however, are considered grade III or high grade tumors, which means that they are usually aggressive, malignant tumors.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":"ORPHA:251957","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0016734","ORPHANET_ID__c":"ORPHA:251957","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Ganglioglioma anaplásico","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"ganglioglioma anaplásico","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Anaplastic ganglioglioma (AGG) is a very rare type of brain tumor that is a type of ganglioglioma. In general, gangliogliomas are classified as grade I or low grade tumors, meaning that they grow slowly and are considered benign. Anaplastic gangliogliomas, however, are considered grade III or high grade tumors, which means that they are usually aggressive, malignant tumors.","Curated_Disease_Description_Source__c":"GARD:0010639","GARD_Synonym__c":"ganglioglioma, anaplastic","Name":"Anaplastic ganglioglioma","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Alex's Lemonade Stand Foundation","Website__c":"https://www.alexslemonade.org/"},{"Account_Name__c":"Brain Foundation","Website__c":"http://www.brainfoundation.org.au/"},{"Account_Name__c":"American Brain Tumor Association","Website__c":"https://www.abta.org/"},{"Account_Name__c":"National Brain Tumor Society","Website__c":"https://braintumor.org/"},{"Account_Name__c":"Children's Brain Tumor Foundation","Website__c":"https://cbtf.org/"},{"Account_Name__c":"International Brain Tumour Alliance","Website__c":"https://theibta.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.orpha.net/en/disease/detail/251957","Source__c":"C0431112; MONDO:0016734; ORPHA:251957","Xref__c":"ORPHA:251957"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=140906","Source__c":"C0431112","Xref__c":"MEDGEN:140906"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0431112","Source__c":"C0431112","Xref__c":"C0431112"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4717","Source__c":"C0431112; MONDO:0016734","Xref__c":"C4717"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0016734","Source__c":"GARD:0010639","Xref__c":"MONDO:0016734"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=1157071000","Source__c":"C0431112","Xref__c":"1157071000"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=128912009","Source__c":"C0431112","Xref__c":"128912009"}],"tags":{"Specialist":["Cancer - Oncologist","Neurology"],"Disease Category":["Cancer","Neurology"]},"synonyms":["ganglioglioma, anaplastic"]}