{"Name":"Teratoma with malignant transformation","DiseaseID__c":"GARD:0010646","id":10646,"encodedName":"teratoma-with-malignant-transformation","IsDeleted":false,"Disease_Name_Full__c":"Teratoma with malignant transformation","Xref_IDs__c":"88334008; C0334523; C4289; DOID:0081246; MEDGEN:87256; MONDO:0006444","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":1,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0006444","Disease_Description__c":"A teratoma which is characterized by morphologic transformation to malignancy and an aggressive clinical course. The malignant component most often is sarcomatous or carcinomatous.","GARD_Name__c":"Teratoma with malignant transformation","GARD_Synonym__c":"dermoid cyst with malignant transformation; dermoid cyst with secondary tumor","Curated_Disease_Description_Source__c":"GARD:0010646","Curated_Disease_Description__c":"A Teratoma with malignant transformation (TMT) is a tumor that develops from germ cells when they grow and divide abnormally, forming a mass. Approximately 6% of teratomas develop into TMTs by a process called malignant transformation, when some of the cells in the teratoma become cancerous. TMTs can occur anywhere in the body, but most are located in the testes in men or ovaries in women. The cause of TMT is unknown.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0006444","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A Teratoma with malignant transformation (TMT) is a tumor that develops from germ cells when they grow and divide abnormally, forming a mass. Approximately 6% of teratomas develop into TMTs by a process called malignant transformation, when some of the cells in the teratoma become cancerous. TMTs can occur anywhere in the body, but most are located in the testes in men or ovaries in women. The cause of TMT is unknown.","Curated_Disease_Description_Source__c":"GARD:0010646","GARD_Synonym__c":"dermoid cyst with malignant transformation; dermoid cyst with secondary tumor","Name":"Teratoma with malignant transformation","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4289","Source__c":"C0334523; MONDO:0006444","Xref__c":"C4289"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0081246","Source__c":"MONDO:0006444","Xref__c":"DOID:0081246"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0334523","Source__c":"C0334523","Xref__c":"C0334523"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=87256","Source__c":"C0334523","Xref__c":"MEDGEN:87256"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=88334008","Source__c":"C0334523","Xref__c":"88334008"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0006444","Source__c":"GARD:0010646","Xref__c":"MONDO:0006444"}],"tags":{"Disease Category":["Cancer"]},"synonyms":["dermoid cyst with malignant transformation"," dermoid cyst with secondary tumor"]}