{"Name":"Progressive transformation of germinal centers","DiseaseID__c":"GARD:0010712","id":10712,"encodedName":"progressive-transformation-of-germinal-centers","IsDeleted":false,"Disease_Name_Full__c":"Progressive transformation of germinal centers","Xref_IDs__c":"C1514481; C38408; C548085; HP:0020262; MEDGEN:271018; MONDO:0043346","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":1,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0043346","Disease_Description__c":"Progressive transformation of germinal centers is a condition in which a lymph node becomes very enlarged (lymphadenopathy). Typically, only one lymph node is affected, though PTGC can involve multiple lymph nodes. Theneck is the most common location of affected lymph nodes, but PTGC may also affect lymph nodes in the groin and armpits. adults are more frequently affected than children, but children have a higher chance of developing PTGC multiple times (recurrence). PTGC is not considered a precancerous condition, though it has been associated with Hodgkin lymphoma.","GARD_Name__c":"Progressive transformation of germinal centers","GARD_Synonym__c":"progressive transformation of germinal centres; ptgc","Curated_Disease_Description_Source__c":"GARD:0010712","Curated_Disease_Description__c":"Progressive transformation of germinal centers is a condition in which a lymph node becomes very enlarged (lymphadenopathy). Typically, only one lymph node is affected, though PTGC can involve multiple lymph nodes. The neck is the most common location of affected lymph nodes, but PTGC may also affect lymph nodes in the groin and armpits. Adults are more frequently affected than children, but children have a higher chance of developing PTGC multiple times (recurrence). PTGC is not considered a precancerous condition, though it has been associated with Hodgkin lymphoma.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0043346","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Progressive transformation of germinal centers is a condition in which a lymph node becomes very enlarged (lymphadenopathy). Typically, only one lymph node is affected, though PTGC can involve multiple lymph nodes. The neck is the most common location of affected lymph nodes, but PTGC may also affect lymph nodes in the groin and armpits. Adults are more frequently affected than children, but children have a higher chance of developing PTGC multiple times (recurrence). PTGC is not considered a precancerous condition, though it has been associated with Hodgkin lymphoma.","Curated_Disease_Description_Source__c":"GARD:0010712","GARD_Synonym__c":"progressive transformation of germinal centres; ptgc","Name":"Progressive transformation of germinal centers","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1514481","Source__c":"C1514481","Xref__c":"C1514481"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=271018","Source__c":"C1514481","Xref__c":"MEDGEN:271018"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C548085","Source__c":"MONDO:0043346","Xref__c":"C548085"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38408","Source__c":"C1514481; MONDO:0043346","Xref__c":"C38408"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0043346","Source__c":"GARD:0010712","Xref__c":"MONDO:0043346"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0020262","Source__c":"C1514481","Xref__c":"HP:0020262"}],"tags":{"Disease Category":["Cancer"]},"synonyms":["progressive transformation of germinal centres"," ptgc"]}