{"Name":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia","DiseaseID__c":"GARD:0010780","id":10780,"encodedName":"diffuse-idiopathic-pulmonary-neuroendocrine-cell-hyperplasia","IsDeleted":false,"Disease_Name_Full__c":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia","Xref_IDs__c":"1348302005; C1333291; C7437; MEDGEN:232427; MONDO:0022986; ORPHA:617916","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":2,"Description_Source__c":"MONDO:0022986","Disease_Description__c":"A very rare condition characterized by generalized proliferation of pulmonary neuroendocrine cells. It manifests as progressive cough and dyspnea. It is considered a precursor for pulmonary carcinoid tumor.","GARD_Name__c":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia","GARD_Synonym__c":"dip-nech; dipnech; dipnech - diffuse idiopathic pulmonary neuroendocrine cell hyperplasia","Curated_Disease_Description_Source__c":"GARD:0010780","Curated_Disease_Description__c":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare and poorly understood lung condition that is characterized by the abnormal overgrowth of certain cells in the lung (called pulmonary neuroendocrine cells) that receive signals from nerve cells (neurons) and produce hormones. People with this diagnosis may have no obvious symptoms or may exhibit features of airway disease such as a chronic, nonproductive cough, shortness of breath with exertion, and wheezing. It is considered to be a precancerous condition as studies suggest it is a precursor for pulmonary carcinoid tumors. The cause of DIPNECH is currently unknown.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"as an Adult and as an Older Adult","SourceID__c":"ORPHA:617916","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0022986","ORPHANET_ID__c":"ORPHA:617916","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Hiperplasia difusa idiopática de células neuroendocrinas pulmonares","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"hiperplasia difusa idiopática de células neuroendocrinas pulmonares","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:97955","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare and poorly understood lung condition that is characterized by the abnormal overgrowth of certain cells in the lung (called pulmonary neuroendocrine cells) that receive signals from nerve cells (neurons) and produce hormones. People with this diagnosis may have no obvious symptoms or may exhibit features of airway disease such as a chronic, nonproductive cough, shortness of breath with exertion, and wheezing. It is considered to be a precancerous condition as studies suggest it is a precursor for pulmonary carcinoid tumors. The cause of DIPNECH is currently unknown.","Curated_Disease_Description_Source__c":"GARD:0010780","GARD_Synonym__c":"dip-nech; dipnech; dipnech - diffuse idiopathic pulmonary neuroendocrine cell hyperplasia","Name":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Alianza Iberoamericana de Enfermedades Raras o Poco Frecuentes","Website__c":"https://aliber.org/web/"},{"Account_Name__c":"Federación Mexicana de Enfermedades Raras (FEMEXER)","Website__c":"http://www.femexer.org/"},{"Account_Name__c":"Federación Española de Enfermedades Raras","Website__c":"https://enfermedades-raras.org/"},{"Account_Name__c":"Federación Colombiana de Enfermedades Raras","Website__c":"http://www.fecoer.org"},{"Account_Name__c":"Federación Argentina de Enfermedades Poco Frecuentes","Website__c":"https://fadepof.org.ar/"},{"Account_Name__c":"Asociación Todos Unidos Enfermedades Raras Uruguay","Website__c":"https://atueru.org.uy/"},{"Account_Name__c":"Asociación de Pacientes con Tumores Neuroendocrinos","Website__c":"https://netespana.org/"},{"Account_Name__c":"Neuroendocrine Tumor Research Foundation","Website__c":"https://netrf.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Pulmonology","Tag_Category__c":"Disease Category;Specialist","category_description":"Respiratory diseases affect the nose, mouth, throat, voice box, windpipe, lungs, or blood vessels.","curated_tag_name":"Respiratory diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Elderly","Provided_By__c":"ORPHA:617916"},{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:617916"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1333291","Source__c":"C1333291","Xref__c":"C1333291"},{"URL__c":"https://www.orpha.net/en/disease/detail/617916","Source__c":"C1333291; MONDO:0022986; ORPHA:617916","Xref__c":"ORPHA:617916"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C7437","Source__c":"C1333291; MONDO:0022986","Xref__c":"C7437"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=232427","Source__c":"C1333291","Xref__c":"MEDGEN:232427"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=1348302005","Source__c":"C1333291","Xref__c":"1348302005"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0022986","Source__c":"GARD:0010780","Xref__c":"MONDO:0022986"}],"tags":{"Specialist":["Cancer - Oncologist","Pulmonology"],"Disease Category":["Cancer","Pulmonology"]},"synonyms":["dip-nech"," dipnech"," dipnech - diffuse idiopathic pulmonary neuroendocrine cell hyperplasia"],"spanishId":13330,"spanishName":"hiperplasia-difusa-idiopatica-de-celulas-neuroendocrinas-pulmonares"}