{"Name":"Logopenic progressive aphasia","DiseaseID__c":"GARD:0010791","id":10791,"encodedName":"logopenic-progressive-aphasia","IsDeleted":false,"Disease_Name_Full__c":"Logopenic progressive aphasia","Xref_IDs__c":"716380002; C4274665; DOID:0081389; MEDGEN:907332; MONDO:0016644; ORPHA:250831","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0016644","Disease_Description__c":"Logopenic progressive aphasia (lv-PPA) is a form of primary progressive aphasia (PPA; see this term), characterized by impaired single-word retrieval and naming and impaired repetition with spared single-word comprehension and object knowledge.","GARD_Name__c":"Logopenic progressive aphasia","GARD_Synonym__c":"logopenic primary progressive aphasia; logopenic variant ppa; lpa","Curated_Disease_Description_Source__c":"GARD:0010791","Curated_Disease_Description__c":"Logopenic progressive aphasia (LPA) is a type of dementia characterized by language disturbance, including difficulty making or understanding speech (aphasia). It is a type of primary progressive aphasia (PPA). Affected individuals have slow, hesitant speech due to difficulty retrieving the correct words, names, or numbers. Difficulty with phase and sentence repetition are additionally present. Speech is typically well articulated and grammatically correct with good single-word comprehension. But over time, affected individuals may have trouble understanding long or complex verbal information, due to problems holding onto lengthy information that they hear. Language difficulties associated with LPA are due to shrinking, or atrophy, in the left posterior temporal cortex and inferior parietal lobule.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:250831","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0016644","ORPHANET_ID__c":"ORPHA:250831","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Afasia logopénica progresiva","Spanish_Description_Source__c":"ORPHA:250831","Spanish_Description__c":"Es una forma de afasia progresiva primaria (APP) caracterizada por una afectación de la recuperación y denominación de palabras sueltas y una alteración de la repetición con poca comprensión de palabras sueltas y conocimiento de objetos.","Spanish_Disease_Name__c":"afasia logopénica progresiva","Spanish_GARD_Synonym__c":"afasia primaria logopénica progresiva; variante logopénica de la app","Category_Linearization__c":"ORPHA:98006","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Logopenic progressive aphasia (LPA) is a type of dementia characterized by language disturbance, including difficulty making or understanding speech (aphasia). It is a type of primary progressive aphasia (PPA). Affected individuals have slow, hesitant speech due to difficulty retrieving the correct words, names, or numbers. Difficulty with phase and sentence repetition are additionally present. Speech is typically well articulated and grammatically correct with good single-word comprehension. But over time, affected individuals may have trouble understanding long or complex verbal information, due to problems holding onto lengthy information that they hear. Language difficulties associated with LPA are due to shrinking, or atrophy, in the left posterior temporal cortex and inferior parietal lobule.","Curated_Disease_Description_Source__c":"GARD:0010791","GARD_Synonym__c":"logopenic primary progressive aphasia; logopenic variant ppa; lpa","Name":"Logopenic progressive aphasia","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Aphasia Center of Maine","Website__c":"https://www.aphasiacenterofmaine.org/"},{"Account_Name__c":"The Association for Frontotemporal Degeneration","Website__c":"https://www.theaftd.org/"},{"Account_Name__c":"National Aphasia Association","Website__c":"https://www.aphasia.org/"},{"Account_Name__c":"Aphasia Hope Foundation","Website__c":"https://aphasiahope.wpengine.com/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"},{"Tag_Name__c":"Psychiatry","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:250831"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.orpha.net/en/disease/detail/250831","Source__c":"C4274665; MONDO:0016644; ORPHA:250831","Xref__c":"ORPHA:250831"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0081389","Source__c":"MONDO:0016644","Xref__c":"DOID:0081389"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=907332","Source__c":"C4274665","Xref__c":"MEDGEN:907332"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=716380002","Source__c":"C4274665; MONDO:0016644","Xref__c":"716380002"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C4274665","Source__c":"C4274665","Xref__c":"C4274665"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0016644","Source__c":"GARD:0010791","Xref__c":"MONDO:0016644"}],"Inheritance__c":["Non-Mendelian inheritance"],"tags":{"Disease Category":["Neurology"],"Specialist":["Neurology","Psychiatry"]},"synonyms":["logopenic primary progressive aphasia"," logopenic variant ppa"," lpa"]}