{"Name":"Eastern equine encephalitis","DiseaseID__c":"GARD:0010821","id":10821,"encodedName":"eastern-equine-encephalitis","IsDeleted":false,"Disease_Name_Full__c":"Eastern equine encephalitis","Xref_IDs__c":"A83.2; C0153065; D020242; DOID:10841; MEDGEN:102258; MONDO:0005736; ORPHA:83594","USA_Estimate__c":"1,000","No_of_Specialist_Tagsa__c":4,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"1 to 8,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0005736","Disease_Description__c":"An acute arboviral infection caused by an <i>alphavirus</i> of the <i>Togaviridae</i> family transmitted by an infected mosquito, that is characterized by the onset of flulike symptoms including fever, chills, weakness, headache, vomiting, abdominal pain with diarrhea, myalgia, leucocytosis, and hematuria, rapidly progressing to diffuse central nervous system (CNS) involvement with confusion, somnolence, or even coma. Seizures, which may progress to status epilepticus and neurologic sequelae, cranial nerve palsies, and photophobia may occur. EEE is associated with a high rate of morbidity and mortality.","GARD_Name__c":"Eastern equine encephalitis","GARD_Synonym__c":"eastern equine encephalitis virus infection; eastern equine encephalitis virus neuroinvasive disease; eastern equine encephalomyelitis; eee - eastern equine encephalitis; encephalitis, eastern equine; neuroinvasive eastern equine encephalitis virus disease; neuroinvasive eastern equine encephalitis virus infection","Curated_Disease_Description_Source__c":"GARD:0010821","Curated_Disease_Description__c":"Eastern equine encephalitis (Triple E) is an illness caused by a virus that comes from an infected mosquito bite. Most people who are infected have no symptoms, but some may develop fever, headaches, and vomiting. Symptoms occur within 4-10 days of being infected and most recover in 1-2 weeks. A small number will develop swelling of the brain and severe neurological symptoms that can be permanent. Triple E can also lead to coma and death. This condition is caused by a type of arbovirus and is transmitted by a mosquito which has bitten an infected bird or reptile. Diagnosis is based on the symptoms, specific findings in the blood, and occasionally by an MRI of the brain.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"1,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:83594","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0005736","ORPHANET_ID__c":"ORPHA:83594","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Encefalitis equina oriental","Spanish_Description_Source__c":"ORPHA:83594","Spanish_Description__c":"Es una infección arboviral aguda causada por un <i>Alfavirus</i> de la familia <i>Togaviridae</i> transmitida por un mosquito infectado. Está caracterizada por la aparición de síntomas similares a la gripe, tales como fiebre, escalofríos, debilidad, cefalea, vómitos, dolor abdominal con diarrea, mialgia, leucocitosis y hematuria, que progresa rápidamente a una afectación difusa del sistema nervioso central (SNC) con confusión, somnolencia e incluso coma. Pueden producirse crisis epilépticas, con posible progresión a estatus epiléptico y con secuelas neurológicas, así como parálisis de nervios craneales y fotofobia. La infección está asociada a una elevada tasa de morbimortalidad.","Spanish_Disease_Name__c":"encefalitis equina oriental","Spanish_GARD_Synonym__c":"encefalomielitis equina oriental","Category_Linearization__c":"ORPHA:68416","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Eastern equine encephalitis (Triple E) is an illness caused by a virus that comes from an infected mosquito bite. Most people who are infected have no symptoms, but some may develop fever, headaches, and vomiting. Symptoms occur within 4-10 days of being infected and most recover in 1-2 weeks. A small number will develop swelling of the brain and severe neurological symptoms that can be permanent. Triple E can also lead to coma and death. This condition is caused by a type of arbovirus and is transmitted by a mosquito which has bitten an infected bird or reptile. Diagnosis is based on the symptoms, specific findings in the blood, and occasionally by an MRI of the brain.","Curated_Disease_Description_Source__c":"GARD:0010821","GARD_Synonym__c":"eastern equine encephalitis virus infection; eastern equine encephalitis virus neuroinvasive disease; eastern equine encephalomyelitis; eee - eastern equine encephalitis; encephalitis, eastern equine; neuroinvasive eastern equine encephalitis virus disease; neuroinvasive eastern equine encephalitis virus infection","Name":"Eastern equine encephalitis","Curated_USA_Estimate__c":"1,000","estimateUsa":"1,000"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Infectious Disease","Tag_Category__c":"Disease Category;Specialist","category_description":"Infectious diseases are caused by bacteria, viruses, fungi, or parasites entering the body, multiplying, and spreading illness.","curated_tag_name":"Infectious diseases"},{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"},{"Tag_Name__c":"Rare Viral Disease","Tag_Category__c":"Cause","curated_tag_name":"Viral Infectious Diseases"},{"Tag_Name__c":"Epilepsy","Tag_Category__c":"Account;Specialist","curated_tag_name":"Epilepsy"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:83594"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0153065","Source__c":"C0153065","Xref__c":"C0153065"},{"URL__c":"https://www.orpha.net/en/disease/detail/83594","Source__c":"C0153065; MONDO:0005736; ORPHA:83594","Xref__c":"ORPHA:83594"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/A83.2","Source__c":"MONDO:0005736","Xref__c":"A83.2"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=102258","Source__c":"C0153065","Xref__c":"MEDGEN:102258"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A10841","Source__c":"MONDO:0005736","Xref__c":"DOID:10841"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C020242","Source__c":"C0153065; MONDO:0005736","Xref__c":"D020242"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0005736","Source__c":"GARD:0010821","Xref__c":"MONDO:0005736"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=417496004","Source__c":"C0153065","Xref__c":"417496004"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=416925005","Source__c":"C0153065","Xref__c":"416925005"}],"tags":{"Disease Category":["Infectious Disease","Neurology"],"Specialist":["Infectious Disease","Neurology","Epilepsy","Pediatrics"],"Cause":["Rare Viral Disease"],"Account":["Epilepsy"]},"synonyms":["eastern equine encephalitis virus infection"," eastern equine encephalitis virus neuroinvasive disease"," eastern equine encephalomyelitis"," eee - eastern equine encephalitis"," encephalitis, eastern equine"," neuroinvasive eastern equine encephalitis virus disease"," neuroinvasive eastern equine encephalitis virus infection"]}