{"Name":"Idiopathic spontaneous coronary artery dissection","DiseaseID__c":"GARD:0010822","id":10822,"encodedName":"idiopathic-spontaneous-coronary-artery-dissection","IsDeleted":false,"Disease_Name_Full__c":"Idiopathic spontaneous coronary artery dissection","Xref_IDs__c":"C165532; C1852540; C565153; MEDGEN:377701; MONDO:0007385; OMIM:122455; ORPHA:458718","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":6,"No_of_Age_at_Onset__c":1,"Description_Source__c":"GARD:0010822","Disease_Description__c":"Spontaneous coronary artery dissection (SCAD) is a condition in which blood accumulates between the layers of tissue that make up the wall of the coronary artery (the vessel that supplies blood to the heart). The trapped blood then creates a blockage which interferes with blood flow to the heart. Depending on the degree of blockage, symptoms can range from chest pain to heart attack or cardiac arrest. For some, the first symptom is a heart attack. If the blockage is partial, symptoms may include shortness of breath, a rapid heartbeat, sweating, nausea, and fatigue (tiredness). SCAD is more common in women. Blank SCAD is an urgent situation and requires immediate attention. Blank Though the exact cause of SCAD is not fully understood, risk factors include pregnancy, recently giving birth, very high blood pressure, and extreme exercise. Blank Certain conditions such as connective tissue disorders or fibromuscular dysplasia (FMD) may also increase a person's risk of developing SCAD.","GARD_Name__c":"Idiopathic spontaneous coronary artery dissection","GARD_Synonym__c":"coronary artery dissection, spontaneous; idiopathic scad","Curated_Disease_Description_Source__c":"PlainLanguagePilotV1-Sep23","Curated_Disease_Description__c":"Idiopathic spontaneous coronary artery dissection is a condition in which blood accumulates between the layers of tissue that make up the wall of the coronary artery (the vessel that supplies blood to the heart). The trapped blood then creates a blockage which interferes with blood flow to the heart. Depending on the degree of blockage, symptoms can range from chest pain to heart attack or cardiac arrest. For some, the first symptom is a heart attack. If the blockage is partial, symptoms may include shortness of breath, a rapid heartbeat, sweating, nausea, and fatigue (tiredness). Idiopathic spontaneous coronary artery dissection is more common in women. Idiopathic spontaneous coronary artery dissection is an urgent situation and requires immediate attention. Though the exact cause is not fully understood, risk factors include pregnancy, recently giving birth, very high blood pressure, and extreme exercise. Certain conditions such as connective tissue disorders or fibromuscular dysplasia (FMD) may also increase a person's risk of developing Idiopathic spontaneous coronary artery dissection.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:458718","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0007385","ORPHANET_ID__c":"ORPHA:458718","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Disección coronaria espontánea idiopática","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"disección coronaria espontánea idiopática","Spanish_GARD_Synonym__c":"dce idiopática; disección espontánea de arterias coronarias idiopática","Category_Linearization__c":"ORPHA:97929","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Idiopathic spontaneous coronary artery dissection is a condition in which blood accumulates between the layers of tissue that make up the wall of the coronary artery (the vessel that supplies blood to the heart). The trapped blood then creates a blockage which interferes with blood flow to the heart. Depending on the degree of blockage, symptoms can range from chest pain to heart attack or cardiac arrest. For some, the first symptom is a heart attack. If the blockage is partial, symptoms may include shortness of breath, a rapid heartbeat, sweating, nausea, and fatigue (tiredness). Idiopathic spontaneous coronary artery dissection is more common in women. Idiopathic spontaneous coronary artery dissection is an urgent situation and requires immediate attention. Though the exact cause is not fully understood, risk factors include pregnancy, recently giving birth, very high blood pressure, and extreme exercise. Certain conditions such as connective tissue disorders or fibromuscular dysplasia (FMD) may also increase a person's risk of developing Idiopathic spontaneous coronary artery dissection.","Curated_Disease_Description_Source__c":"PlainLanguagePilotV1-Sep23","GARD_Synonym__c":"coronary artery dissection, spontaneous; idiopathic scad","Name":"Idiopathic spontaneous coronary artery dissection","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"SCAD Research","Website__c":"https://www.scadresearch.org/"},{"Account_Name__c":"SCAD Alliance","Website__c":"https://scadalliance.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cardiology","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Vascular Medicine","Tag_Category__c":"Specialist","curated_tag_name":"Vascular diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:458718"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C565153","Source__c":"MONDO:0007385","Xref__c":"C565153"},{"URL__c":"https://www.orpha.net/en/disease/detail/458718","Source__c":"C1852540; MONDO:0007385","Xref__c":"ORPHA:458718"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=377701","Source__c":"C1852540","Xref__c":"MEDGEN:377701"},{"URL__c":"https://www.omim.org/entry/122455","Source__c":"C1852540; MONDO:0007385; ORPHA:458718","Xref__c":"OMIM:122455"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1852540","Source__c":"C1852540","Xref__c":"C1852540"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0007385","Source__c":"GARD:0010822","Xref__c":"MONDO:0007385"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C165532","Source__c":"C1852540","Xref__c":"C165532"}],"Inheritance__c":["Autosomal dominant"],"GARD_Disease_Feature__c":[{"Provided_By__c":"OMIM:122455","Feature__r":{"HPO_Description__c":"Acute occurrence of a dissection (tear within the tunica intima and entry of blood into the tunica media) of a coronary artery.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0006702","HPO_Name__c":"Coronary artery dissection","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"OMIM:122455","Feature__r":{"HPO_Description__c":"A disorder of large arteries, in particular the aorta, characterized by an accumulation of basophilic ground substance in the media with cyst-like lesions associated with degenerative changes of collagen, elastin and the vascular smooth muscle cells.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012180","HPO_Synonym__c":"Arterial cystic medial necrosis","HPO_Name__c":"Cystic medial necrosis","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Specialist":["Cardiology","Vascular Medicine"]},"synonyms":["coronary artery dissection, spontaneous"," idiopathic scad"]}