{"Name":"Superior limbic keratoconjunctivitis","DiseaseID__c":"GARD:0010940","id":10940,"encodedName":"superior-limbic-keratoconjunctivitis","IsDeleted":false,"Disease_Name_Full__c":"Superior limbic keratoconjunctivitis","Xref_IDs__c":"231903005; C0339229; MEDGEN:573037; MONDO:0019504; ORPHA:88633","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0019504","Disease_Description__c":"Superior limbic keratoconjunctivitis (SLK) is a chronic and recurrent eye disease which affects thesuperior bulbar conjunctiva (the clear layer that covers the eyeball, over the sclera) and tarsal conjunctiva (the clear layer that lines the eyelids), as well as the superior limbic aspect of the cornea (the area above the cornea). It is commonly found in women 20-70 years of age. The signs and symptoms include burning, redness and irritation and tend to develop slowly over a period of 1 to 10 years.Vision usually remains intact. While the underlying cause ofSLK remains unknown, it is believed that the condition issecondary to superior bulbar conjunctiva laxity. Factors inducing conjunctiva laxity include thyroid eye disease (usually hyperthyroidism), tight upper eyelids, and prominent globes. A mimicking disorder has been encountered in soft contact lens (SCL) wearers, typically with exposure to thimerosal-preserved solutions. Treatment of SLK may involve the use of various medications, surgery, or a combination of both.","GARD_Name__c":"Superior limbic keratoconjunctivitis","GARD_Synonym__c":"slk; slk - superior limbic keratoconjunctivitis; superior limbal keratoconjunctivitis; superior limbic keratitis; theodore superior limbic keratoconjunctivitis; theodore syndrome; theodore's superior limbic keratoconjunctivitis; theodore's syndrome; theodores superior limbic keratoconjunctivitis; theodores syndrome","Curated_Disease_Description_Source__c":"GARD:0010940","Curated_Disease_Description__c":"Superior limbic keratoconjunctivitis (SLK) is a chronic and recurrent eye disease which affects the superior bulbar conjunctiva (the clear layer that covers the eyeball, over the sclera) and tarsal conjunctiva (the clear layer that lines the eyelids), as well as the superior limbic aspect of the cornea (the area above the cornea). The signs and symptoms include burning, redness and irritation and tend to develop slowly over a period of 1 to 10 years. Vision usually remains intact. While the underlying cause of SLK remains unknown, it is believed that the condition is secondary to superior bulbar conjunctiva laxity. Factors inducing conjunctiva laxity include thyroid eye disease (usually hyperthyroidism), tight upper eyelids, and prominent globes. A mimicking disorder has been encountered in soft contact lens (SCL) wearers, typically with exposure to thimerosal-preserved solutions.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":"ORPHA:88633","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0019504","ORPHANET_ID__c":"ORPHA:88633","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Queratoconjuntivitis límbica superior","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"queratoconjuntivitis límbica superior","Spanish_GARD_Synonym__c":"queratoconjuntivitis límbica superior de theodore; slk; síndrome de theodore","Category_Linearization__c":"ORPHA:97966","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Superior limbic keratoconjunctivitis (SLK) is a chronic and recurrent eye disease which affects the superior bulbar conjunctiva (the clear layer that covers the eyeball, over the sclera) and tarsal conjunctiva (the clear layer that lines the eyelids), as well as the superior limbic aspect of the cornea (the area above the cornea). The signs and symptoms include burning, redness and irritation and tend to develop slowly over a period of 1 to 10 years. Vision usually remains intact. While the underlying cause of SLK remains unknown, it is believed that the condition is secondary to superior bulbar conjunctiva laxity. Factors inducing conjunctiva laxity include thyroid eye disease (usually hyperthyroidism), tight upper eyelids, and prominent globes. A mimicking disorder has been encountered in soft contact lens (SCL) wearers, typically with exposure to thimerosal-preserved solutions.","Curated_Disease_Description_Source__c":"GARD:0010940","GARD_Synonym__c":"slk; slk - superior limbic keratoconjunctivitis; superior limbal keratoconjunctivitis; superior limbic keratitis; theodore superior limbic keratoconjunctivitis; theodore syndrome; theodore's superior limbic keratoconjunctivitis; theodore's syndrome; theodores superior limbic keratoconjunctivitis; theodores syndrome","Name":"Superior limbic keratoconjunctivitis","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Ophthalmology","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Anterior segment of Eye","Tag_Category__c":"Specialist","curated_tag_name":"Front part of eye disease"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=573037","Source__c":"C0339229","Xref__c":"MEDGEN:573037"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=231903005","Source__c":"C0339229; MONDO:0019504","Xref__c":"231903005"},{"URL__c":"https://www.orpha.net/en/disease/detail/88633","Source__c":"C0339229; MONDO:0019504; ORPHA:88633","Xref__c":"ORPHA:88633"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0339229","Source__c":"C0339229","Xref__c":"C0339229"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019504","Source__c":"GARD:0010940","Xref__c":"MONDO:0019504"}],"tags":{"Specialist":["Ophthalmology","Anterior segment of Eye"]},"synonyms":["slk"," slk - superior limbic keratoconjunctivitis"," superior limbal keratoconjunctivitis"," superior limbic keratitis"," theodore superior limbic keratoconjunctivitis"," theodore syndrome"," theodore's superior limbic keratoconjunctivitis"," theodore's syndrome"," theodores superior limbic keratoconjunctivitis"," theodores syndrome"]}