{"Name":"Non-24-hour sleep-wake syndrome","DiseaseID__c":"GARD:0010949","id":10949,"encodedName":"non-24-hour-sleep-wake-syndrome","IsDeleted":false,"Disease_Name_Full__c":"Non-24-hour sleep-wake syndrome","Xref_IDs__c":"230496009; C0751759; G47.24; MEDGEN:148383; MONDO:0019137; ORPHA:73267","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0019137","Disease_Description__c":"A rare neurological disease which is a circadian rhythm sleep disorder characterized by non-synchronization to a 24-hour day leading to insomnia and daytime sleepiness with sometimes severe associated manifestations.","GARD_Name__c":"Non-24-hour sleep-wake syndrome","GARD_Synonym__c":"circadian rhythm sleep disorder, free running type; circadian rhythm sleep disorder, free-running type; hypernychthemeral syndrome; non-24; non-24-hour sleep-wake disorder","Curated_Disease_Description_Source__c":"GARD:0010949","Curated_Disease_Description__c":"Non 24 hour sleep wake disorder refers to a steady pattern of one- to two-hour delays in sleep onset and wake times in people with normal living conditions. This occurs because the period of the person's sleep-wake cycle is longer than 24 hours. The condition most commonly affects people who are blind, due to an impaired sense of light-dark cycles. Non 24 hour sleep wake disorder can also affect sighted people. The cause of the disorder in these cases is incompletely understood, but studies suggest melatonin levels play a role.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:73267","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0019137","ORPHANET_ID__c":"ORPHA:73267","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Síndrome de vigilia-sueño no de 24 horas","Spanish_Description_Source__c":"ORPHA:73267","Spanish_Description__c":"Es un trastorno del ritmo circadiano del sueño caracterizado por la falta de sincronización del ciclo con un día de 24 horas. Esto conduce a insomnio y somnolencia diurna que, en ocasiones, se asocia a otras manifestaciones graves.","Spanish_Disease_Name__c":"síndrome de vigilia-sueño no de 24 horas","Spanish_GARD_Synonym__c":"síndrome hipernictemeral","Category_Linearization__c":"ORPHA:98006","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Non 24 hour sleep wake disorder refers to a steady pattern of one- to two-hour delays in sleep onset and wake times in people with normal living conditions. This occurs because the period of the person's sleep-wake cycle is longer than 24 hours. The condition most commonly affects people who are blind, due to an impaired sense of light-dark cycles. Non 24 hour sleep wake disorder can also affect sighted people. The cause of the disorder in these cases is incompletely understood, but studies suggest melatonin levels play a role.","Curated_Disease_Description_Source__c":"GARD:0010949","GARD_Synonym__c":"circadian rhythm sleep disorder, free running type; circadian rhythm sleep disorder, free-running type; hypernychthemeral syndrome; non-24; non-24-hour sleep-wake disorder","Name":"Non-24-hour sleep-wake syndrome","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Project Sleep","Website__c":"https://project-sleep.com/"},{"Account_Name__c":"American Sleep Association","Website__c":"http://www.sleepassociation.org/"},{"Account_Name__c":"Circadian Sleep Disorders Network","Website__c":"https://www.circadiansleepdisorders.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"},{"Tag_Name__c":"Sleep medicine","Tag_Category__c":"Specialist","curated_tag_name":"Sleep medicine"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:73267"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=148383","Source__c":"C0751759","Xref__c":"MEDGEN:148383"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/G47.24","Source__c":"MONDO:0019137","Xref__c":"G47.24"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=230496009","Source__c":"MONDO:0019137","Xref__c":"230496009"},{"URL__c":"https://www.orpha.net/en/disease/detail/73267","Source__c":"C0751759; MONDO:0019137","Xref__c":"ORPHA:73267"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0751759","Source__c":"C0751759","Xref__c":"C0751759"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019137","Source__c":"GARD:0010949","Xref__c":"MONDO:0019137"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:73267","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"A state of abnormally strong desire for sleep during the daytime.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001262","HPO_Synonym__c":"Excessive daytime sleepiness; More than typical sleepiness during day","HPO_Name__c":"Excessive daytime somnolence","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:73267","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Blindness is the condition of lacking visual perception defined as a profound reduction in visual perception. On the 6m visual acuity scale, blindness is defined as less than 3/60. On the 20ft visual acuity scale, blindness is defined as less than 20/400. On the decimal visual acuity scale, blindness is defined as less than 0.05. Blindness is typically characterized by a visual field of no greater than 10 degrees in radius around central fixation.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000618","HPO_Synonym__c":"Blindness; Total vision loss","HPO_Name__c":"Blindness","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:73267","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An anomaly in the amount or timing of melatonin secretion by the pineal gland. Note that melatonin is also synthesized by multiple tissues outside of the pineal gland.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012689","HPO_Name__c":"Abnormal pineal melatonin secretion","Feature_System__c":"Nervous System; Endocrine System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:73267","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"A state characterized by a feeling of weakness and loss of strength leading to a generalized weakness of the body.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0025406","HPO_Synonym__c":"Lack of energy and strength; Weakness","HPO_Name__c":"Asthenia","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:73267","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover from these moods; having a pessimistic outlook on the future; feeling a pervasive sense of shame; having a low self-worth; experiencing thoughts of suicide and engaging in suicidal behavior.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000716","HPO_Synonym__c":"Depression; Depressive episode; Depressivity","HPO_Name__c":"Depression","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Disease Category":["Neurology"],"Specialist":["Neurology","Sleep medicine","Pediatrics"]},"synonyms":["circadian rhythm sleep disorder, free running type"," circadian rhythm sleep disorder, free-running type"," hypernychthemeral syndrome"," non-24"," non-24-hour sleep-wake disorder"]}