{"Name":"Differentiated thyroid carcinoma","DiseaseID__c":"GARD:0012027","id":12027,"encodedName":"differentiated-thyroid-carcinoma","IsDeleted":false,"Disease_Name_Full__c":"Differentiated thyroid carcinoma","Xref_IDs__c":"1255086008; C1337013; C7153; DOID:0080525; MEDGEN:277876; MONDO:0015447; ORPHA:146","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":3,"Description_Source__c":"MONDO:0015447","Disease_Description__c":"A rare, slow-growing, epithelial thyroid carcinoma typically presenting as an asymptomatic thyroid mass and is classed as either papillary thyroid cancer (PTC), follicular thyroid cancer (FTC) or Hurthle cell thyroid cancer (HCTC).","GARD_Name__c":"Differentiated thyroid carcinoma","GARD_Synonym__c":"differentiated thyroid cancer; differentiated thyroid gland cancer; differentiated thyroid gland carcinoma; dtc - differentiated thyroid cancer; papillary or follicular thyroid carcinoma; thyroid gland differentiated carcinoma; thyroid gland well differentiated carcinoma; well differentiated thyroid carcinoma; well differentiated thyroid gland carcinoma; well-differentiated thyroid cancer; well-differentiated thyroid carcinoma","Curated_Disease_Description_Source__c":"GARD:0012027","Curated_Disease_Description__c":"Differentiated thyroid carcinoma is a form of cancer that occurs due to abnormal and uncontrolled cell growth of certain cells (follicular cells) of the thyroid. Many people with differentiated thyroid carcinoma have no signs or symptoms of the condition. When present, symptoms may include a small lump at the base of the neck, hoarseness, difficulty swallowing, trouble breathing, and pain in the neck or throat. The cause of differentiated thyroid carcinoma is currently unknown.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"from Childhood to Adulthood","SourceID__c":"ORPHA:146","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0015447","ORPHANET_ID__c":"ORPHA:146","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Carcinoma diferenciado de tiroides","Spanish_Description_Source__c":"ORPHA:146","Spanish_Description__c":"Es un carcinoma epitelial de tiroides poco frecuente, de crecimiento lento, que se presenta típicamente como una masa tiroidea asintomática y se clasifica como carcinoma papilar de tiroides (CPT), carcinoma folicular de tiroides (CFT) o carcinoma de células de Hurthle (CCH).","Spanish_Disease_Name__c":"carcinoma diferenciado de tiroides","Spanish_GARD_Synonym__c":"carcinoma tiroideo bien diferenciado; carcinoma tiroideo papilar o folicular","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Differentiated thyroid carcinoma is a form of cancer that occurs due to abnormal and uncontrolled cell growth of certain cells (follicular cells) of the thyroid. Many people with differentiated thyroid carcinoma have no signs or symptoms of the condition. When present, symptoms may include a small lump at the base of the neck, hoarseness, difficulty swallowing, trouble breathing, and pain in the neck or throat. The cause of differentiated thyroid carcinoma is currently unknown.","Curated_Disease_Description_Source__c":"GARD:0012027","GARD_Synonym__c":"differentiated thyroid cancer; differentiated thyroid gland cancer; differentiated thyroid gland carcinoma; dtc - differentiated thyroid cancer; papillary or follicular thyroid carcinoma; thyroid gland differentiated carcinoma; thyroid gland well differentiated carcinoma; well differentiated thyroid carcinoma; well differentiated thyroid gland carcinoma; well-differentiated thyroid cancer; well-differentiated thyroid carcinoma","Name":"Differentiated thyroid carcinoma","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"American Thyroid Association","Website__c":"https://www.thyroid.org/"},{"Account_Name__c":"ThyCa: Thyroid Cancer Survivors' Association, Inc.","Website__c":"https://www.thyca.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Endocrine","Tag_Category__c":"Disease Category;Specialist","category_description":"Endocrine diseases affect hormone production or how the body responds to a specific hormone(s).","curated_tag_name":"Endocrine diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adolescent","Provided_By__c":"ORPHA:146"},{"Age_At_Onset__c":"Childhood","Provided_By__c":"ORPHA:146"},{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:146"}],"Diagnosis__c":[{"Type__c":"GTR","Curie__c":"MEDGEN:C0238463"}],"External_Identifier_Disease__c":[{"URL__c":"https://raresource.nih.gov/diseases/filter/0012027","Source__c":"RareSource"},{"URL__c":"https://www.orpha.net/en/disease/detail/146","Source__c":"C1337013; MONDO:0015447; ORPHA:146","Xref__c":"ORPHA:146"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C7153","Source__c":"C1337013; MONDO:0015447","Xref__c":"C7153"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=277876","Source__c":"C1337013","Xref__c":"MEDGEN:277876"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0080525","Source__c":"MONDO:0015447","Xref__c":"DOID:0080525"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1337013","Source__c":"C1337013","Xref__c":"C1337013"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=1255086008","Source__c":"C1337013","Xref__c":"1255086008"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0015447","Source__c":"GARD:0012027","Xref__c":"MONDO:0015447"}],"GARD_Disease_Gene__c":[{"GeneSymbol__c":"GAS8-AS1","Gene_Type__c":"non-coding RNA","Causal_Gene__c":true},{"GeneSymbol__c":"KRAS","GHR_URL__c":"https://medlineplus.gov/genetics/gene/kras","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"EIF1AX","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"LPAR4","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"NDUFA13","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"HRAS","GHR_URL__c":"https://medlineplus.gov/genetics/gene/hras","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"NRAS","GHR_URL__c":"https://medlineplus.gov/genetics/gene/nras","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"BRAF","GHR_URL__c":"https://medlineplus.gov/genetics/gene/braf","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"TERT","GHR_URL__c":"https://medlineplus.gov/genetics/gene/tert","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true}],"tags":{"Specialist":["Cancer - Oncologist","Endocrine","Pediatrics"],"Disease Category":["Cancer","Endocrine"]},"synonyms":["differentiated thyroid cancer"," differentiated thyroid gland cancer"," differentiated thyroid gland carcinoma"," dtc - differentiated thyroid cancer"," papillary or follicular thyroid carcinoma"," thyroid gland differentiated carcinoma"," thyroid gland well differentiated carcinoma"," well differentiated thyroid carcinoma"," well differentiated thyroid gland carcinoma"," well-differentiated thyroid cancer"," well-differentiated thyroid carcinoma"]}