{"Name":"Ossifying fibroma","DiseaseID__c":"GARD:0012792","id":12792,"encodedName":"ossifying-fibroma","IsDeleted":false,"Disease_Name_Full__c":"Ossifying fibroma","Xref_IDs__c":"25603007; C0206640; C173820; C8422; D018214; DOID:180; HP:0030426; MEDGEN:104906; MONDO:0002119","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":1,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0002119","Disease_Description__c":"A well circumscribed lesion of the bone, most frequently arising from the posterior mandible. It is characterized by the presence of fibrous tissue and a mineralized component which may be woven bone, lamellar bone, or cementum-like material. Complete removal is recommended, since it continues to enlarge if left untreated.","GARD_Name__c":"Ossifying fibroma","GARD_Synonym__c":"cementifying fibroma; cementifying fibroma, calcified structure; cemento-ossifying fibroma; fibro-osteoma; fibroma, ossifying, benign; ossifying fibroma (disease); ossifying fibroma, calcified structure","Curated_Disease_Description_Source__c":"GARD:0012792","Curated_Disease_Description__c":"\"Juvenile ossifying fibroma (JOF) is rare, benign tumor of the craniofacial (skull and face) bones. It is considered a \"\"fibro-osseous neoplasm\"\" because it is characterized by an overgrowth of bone. Affected people generally experience a gradual or rapid, painless expansion of the affected bone or region. Other symptoms such as exophthalmos or nasal blockage can rarely be associated with the tumor depending on its exact location. In some cases, the condition can be particularly aggressive with rapid growth and significant facial disfigurement. The exact underlying cause is currently unknown; however, most cases occur sporadically in people with no family history of the condition.\"","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0002119","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"\"Juvenile ossifying fibroma (JOF) is rare, benign tumor of the craniofacial (skull and face) bones. It is considered a \"\"fibro-osseous neoplasm\"\" because it is characterized by an overgrowth of bone. Affected people generally experience a gradual or rapid, painless expansion of the affected bone or region. Other symptoms such as exophthalmos or nasal blockage can rarely be associated with the tumor depending on its exact location. In some cases, the condition can be particularly aggressive with rapid growth and significant facial disfigurement. The exact underlying cause is currently unknown; however, most cases occur sporadically in people with no family history of the condition.\"","Curated_Disease_Description_Source__c":"GARD:0012792","GARD_Synonym__c":"cementifying fibroma; cementifying fibroma, calcified structure; cemento-ossifying fibroma; fibro-osteoma; fibroma, ossifying, benign; ossifying fibroma (disease); ossifying fibroma, calcified structure","Name":"Ossifying fibroma","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C018214","Source__c":"C0206640; MONDO:0002119","Xref__c":"D018214"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=104906","Source__c":"C0206640","Xref__c":"MEDGEN:104906"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A180","Source__c":"MONDO:0002119","Xref__c":"DOID:180"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C8422","Source__c":"C0206640; MONDO:0002119","Xref__c":"C8422"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C173820","Source__c":"MONDO:0002119","Xref__c":"C173820"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0206640","Source__c":"C0206640","Xref__c":"C0206640"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=25603007","Source__c":"C0206640","Xref__c":"25603007"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0002119","Source__c":"GARD:0012792","Xref__c":"MONDO:0002119"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0030426","Source__c":"C0206640","Xref__c":"HP:0030426"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=302862001","Source__c":"C0206640","Xref__c":"302862001"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=302863006","Source__c":"C0206640","Xref__c":"302863006"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=80699009","Source__c":"C0206640","Xref__c":"80699009"}],"tags":{"Disease Category":["Cancer"]},"synonyms":["cementifying fibroma"," cementifying fibroma, calcified structure"," cemento-ossifying fibroma"," fibro-osteoma"," fibroma, ossifying, benign"," ossifying fibroma (disease)"," ossifying fibroma, calcified structure"]}