{"Name":"Reticulohistiocytic granuloma","DiseaseID__c":"GARD:0012967","id":12967,"encodedName":"reticulohistiocytic-granuloma","IsDeleted":false,"Disease_Name_Full__c":"Reticulohistiocytic granuloma","Xref_IDs__c":"15960008; 404162004; C0035290; C3356; DOID:4394; MEDGEN:48431; MONDO:0002984","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0002984","Disease_Description__c":"A rare cutaneous lesion composed of eosinophilic histiocytes, which are often multinucleated. The lesions are yellow-brown papules affecting any part of the body. Patients are usually adult men. The prognosis is excellent. -- 2003","GARD_Name__c":"Reticulohistiocytic granuloma","GARD_Synonym__c":"giant cell histiocytoma; reticulohistiocytic granuloma (morphologic abnormality); reticulohistiocytoma; reticulohistiocytoma cutis; solitary reticulohistiocytoma","Curated_Disease_Description_Source__c":"GARD:0012967","Curated_Disease_Description__c":"Reticulohistiocytoma (RH) is a rare benign lesion of the soft tissue. It belongs to a group of disorders called non-Langerhans cell histiocytosis and is a type of reticulohistiocytosis, all of which are types of histiocytosis. Histiocytosis is a condition in which there is rapid production (proliferation) of histiocytes (immune cells) in the skin or soft tissues. The stimulus that causes the immune system to react in RH is currently not well understood. RH present as a yellow to reddish-brown smooth surfaced, firm nodule or lesion on the trunk and/or extremities of the body. Historically, RH has been found in young adults, with a slightly higher incidence in males.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0002984","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Reticulohistiocytoma (RH) is a rare benign lesion of the soft tissue. It belongs to a group of disorders called non-Langerhans cell histiocytosis and is a type of reticulohistiocytosis, all of which are types of histiocytosis. Histiocytosis is a condition in which there is rapid production (proliferation) of histiocytes (immune cells) in the skin or soft tissues. The stimulus that causes the immune system to react in RH is currently not well understood. RH present as a yellow to reddish-brown smooth surfaced, firm nodule or lesion on the trunk and/or extremities of the body. Historically, RH has been found in young adults, with a slightly higher incidence in males.","Curated_Disease_Description_Source__c":"GARD:0012967","GARD_Synonym__c":"giant cell histiocytoma; reticulohistiocytic granuloma (morphologic abnormality); reticulohistiocytoma; reticulohistiocytoma cutis; solitary reticulohistiocytoma","Name":"Reticulohistiocytic granuloma","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Histiocytosis Association","Website__c":"https://www.histio.org/"},{"Account_Name__c":"Histiocytosis Association of Canada","Website__c":"https://histiocytosis.ca/"}],"External_Identifier_Disease__c":[{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=404162004","Source__c":"C0035290; MONDO:0002984","Xref__c":"404162004"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0035290","Source__c":"C0035290","Xref__c":"C0035290"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3356","Source__c":"C0035290; MONDO:0002984","Xref__c":"C3356"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=48431","Source__c":"C0035290","Xref__c":"MEDGEN:48431"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A4394","Source__c":"MONDO:0002984","Xref__c":"DOID:4394"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0002984","Source__c":"GARD:0012967","Xref__c":"MONDO:0002984"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=15960008","Source__c":"C0035290","Xref__c":"15960008"}],"tags":{},"synonyms":["giant cell histiocytoma"," reticulohistiocytic granuloma (morphologic abnormality)"," reticulohistiocytoma"," reticulohistiocytoma cutis"," solitary reticulohistiocytoma"]}