{"Name":"Giant cell tumor of bone","DiseaseID__c":"GARD:0013046","id":13046,"encodedName":"giant-cell-tumor-of-bone","IsDeleted":false,"Disease_Name_Full__c":"Giant cell tumor of bone","Xref_IDs__c":"57500000; 697970009; C0206638; C121932; D018212; DOID:4305; HP:0011847; MEDGEN:64624; MONDO:0005674; ORPHA:363976","USA_Estimate__c":"5,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"8,000 to 80,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":3,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0005674","Disease_Description__c":"A benign but locally aggressive tumor that arises from the bone and is composed of mononuclear cells admixed with macrophages and osteoclast-like giant cells. It usually arises from the ends of long bones or the vertebrae. Clinical presentation includes pain, edema, and decreased range of motion in the affected joint.","GARD_Name__c":"Giant cell tumor of bone","GARD_Synonym__c":"benign bone giant cell tumor; benign bone giant cell tumour; bone giant cell tumor; gct of bone; giant cell neoplasm of bone; giant cell tumor of bone (morphologic abnormality); giant cell tumor of bone nos (morphologic abnormality); giant cell tumor of the bone; giant cell tumor, benign; giant cell tumour of bone; giant cell tumour of bone (morphologic abnormality); giant cell tumour of bone nos (morphologic abnormality); giant cell tumour of the bone; gtct - giant cell tumor of bone; osteoclastoma; osteoclastoma, benign","Curated_Disease_Description_Source__c":"MONDO:0005674","Curated_Disease_Description__c":"A benign but locally aggressive tumor that arises from the bone and is composed of mononuclear cells admixed with macrophages and osteoclast-like giant cells. It usually arises from the ends of long bones or the vertebrae. Clinical presentation includes pain, edema, and decreased range of motion in the affected joint.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"5,000","Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:363976","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0005674","ORPHANET_ID__c":"ORPHA:363976","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Tumor óseo de células gigantes","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"tumor óseo de células gigantes","Spanish_GARD_Synonym__c":"osteoclastoma; tcg de hueso","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A benign but locally aggressive tumor that arises from the bone and is composed of mononuclear cells admixed with macrophages and osteoclast-like giant cells. It usually arises from the ends of long bones or the vertebrae. Clinical presentation includes pain, edema, and decreased range of motion in the affected joint.","Curated_Disease_Description_Source__c":"MONDO:0005674","GARD_Synonym__c":"benign bone giant cell tumor; benign bone giant cell tumour; bone giant cell tumor; gct of bone; giant cell neoplasm of bone; giant cell tumor of bone (morphologic abnormality); giant cell tumor of bone nos (morphologic abnormality); giant cell tumor of the bone; giant cell tumor, benign; giant cell tumour of bone; giant cell tumour of bone (morphologic abnormality); giant cell tumour of bone nos (morphologic abnormality); giant cell tumour of the bone; gtct - giant cell tumor of bone; osteoclastoma; osteoclastoma, benign","Name":"Giant cell tumor of bone","Curated_USA_Estimate__c":"5,000","estimateUsa":"5,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Sarcoma UK","Website__c":"https://sarcoma.org.uk/"},{"Account_Name__c":"The Limb Preservation Foundation","Website__c":"http://limbpreservation.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Orthopedics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:363976"}],"External_Identifier_Disease__c":[{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=697970009","Source__c":"C0206638; MONDO:0005674","Xref__c":"697970009"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A4305","Source__c":"MONDO:0005674","Xref__c":"DOID:4305"},{"URL__c":"https://www.orpha.net/en/disease/detail/363976","Source__c":"C0206638; MONDO:0005674; ORPHA:363976","Xref__c":"ORPHA:363976"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=64624","Source__c":"C0206638","Xref__c":"MEDGEN:64624"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C121932","Source__c":"C0206638; MONDO:0005674","Xref__c":"C121932"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C018212","Source__c":"C0206638; MONDO:0005674","Xref__c":"D018212"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0206638","Source__c":"C0206638","Xref__c":"C0206638"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0011847","Source__c":"C0206638","Xref__c":"HP:0011847"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=57500000","Source__c":"C0206638","Xref__c":"57500000"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0005674","Source__c":"GARD:0013046","Xref__c":"MONDO:0005674"}],"tags":{"Specialist":["Cancer - Oncologist","Orthopedics"],"Disease Category":["Cancer"]},"synonyms":["benign bone giant cell tumor"," benign bone giant cell tumour"," bone giant cell tumor"," gct of bone"," giant cell neoplasm of bone"," giant cell tumor of bone (morphologic abnormality)"," giant cell tumor of bone nos (morphologic abnormality)"," giant cell tumor of the bone"," giant cell tumor, benign"," giant cell tumour of bone"," giant cell tumour of bone (morphologic abnormality)"," giant cell tumour of bone nos (morphologic abnormality)"," giant cell tumour of the bone"," gtct - giant cell tumor of bone"," osteoclastoma"," osteoclastoma, benign"]}