{"Name":"Lewis-Sumner syndrome","DiseaseID__c":"GARD:0013070","id":13070,"encodedName":"lewis-sumner-syndrome","IsDeleted":false,"Disease_Name_Full__c":"Lewis-Sumner syndrome","Xref_IDs__c":"C1695985; MEDGEN:798498; MONDO:0018826; ORPHA:48162","USA_Estimate__c":"5,000","No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"8,000 to 80,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0018826","Disease_Description__c":"A rare acquired demyelinating polyneuropathy characterized by asymmetrical distal weakness of the upper or lower extremities and motor dysfunction with adult onset. It is considered to be a variant of chronic inflammatory demyelinating polyneuropathy.","GARD_Name__c":"Lewis-Sumner syndrome","GARD_Synonym__c":"madsam; multifocal acquired demyelinating sensory and motor neuropathy","Curated_Disease_Description_Source__c":"GARD:0013070","Curated_Disease_Description__c":"Lewis-Sumner syndrome (also known as multifocal acquired demyelinating sensory and motor neuropathy) is a neurological condition affecting primarily the arms and hands (upper limbs). The symptoms are a result of inflammation of the nerves leading to the upper body and the destruction of the fatty covering that protects the nerves (myelin sheath). Lewis Sumner syndrome is an acquired disorder, and the exact cause of the condition is not known. Lewis Sumner syndrome may be difficult to distinguish from other forms of demyelinating neuropathies, but diagnosis may be possible through nerve conduction studies or a specific type of imaging test, called MRI with T2 STIR.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"5,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:48162","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0018826","ORPHANET_ID__c":"ORPHA:48162","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Síndrome de lewis-summer","Spanish_Description_Source__c":"ORPHA:48162","Spanish_Description__c":"El síndrome de Lewis-Sumner (SLS) es una polineuropatía desmielinizante adquirida poco frecuente caracterizada por debilidad distal asimétrica de las extremidades superiores o inferiores y disfunción motora de aparición en la edad adulta. Se considera una variante de la polineuropatía desmielinizante crónica.","Spanish_Disease_Name__c":"síndrome de lewis-summer","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:98006","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Lewis-Sumner syndrome (also known as multifocal acquired demyelinating sensory and motor neuropathy) is a neurological condition affecting primarily the arms and hands (upper limbs). The symptoms are a result of inflammation of the nerves leading to the upper body and the destruction of the fatty covering that protects the nerves (myelin sheath). Lewis Sumner syndrome is an acquired disorder, and the exact cause of the condition is not known. Lewis Sumner syndrome may be difficult to distinguish from other forms of demyelinating neuropathies, but diagnosis may be possible through nerve conduction studies or a specific type of imaging test, called MRI with T2 STIR.","Curated_Disease_Description_Source__c":"GARD:0013070","GARD_Synonym__c":"madsam; multifocal acquired demyelinating sensory and motor neuropathy","Name":"Lewis-Sumner syndrome","Curated_USA_Estimate__c":"5,000","estimateUsa":"5,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Global Autoimmune Institute","Website__c":"https://www.autoimmuneinstitute.org/"},{"Account_Name__c":"Inflammatory Neuropathies UK","Website__c":"https://www.inflammatoryneuropathies.uk/"},{"Account_Name__c":"GBS / CIDP Foundation of Canada","Website__c":"https://www.gbscidp.ca/"},{"Account_Name__c":"Guillain Barré Syndrome Support Group NZ Trust","Website__c":"https://gbsnz.org.nz/"},{"Account_Name__c":"GBS/CIDP Foundation International","Website__c":"https://www.gbs-cidp.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"},{"Tag_Name__c":"Peripheral Neuropathy","Tag_Category__c":"Account","curated_tag_name":"Peripheral neuropathy"},{"Tag_Name__c":"Neuromuscular medicine","Tag_Category__c":"Specialist","curated_tag_name":"Neuromuscular medicine"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:48162"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1695985","Source__c":"C1695985","Xref__c":"C1695985"},{"URL__c":"https://www.orpha.net/en/disease/detail/48162","Source__c":"C1695985; MONDO:0018826; ORPHA:48162","Xref__c":"ORPHA:48162"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=798498","Source__c":"C1695985","Xref__c":"MEDGEN:798498"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0018826","Source__c":"GARD:0013070","Xref__c":"MONDO:0018826"}],"tags":{"Disease Category":["Neurology"],"Specialist":["Neurology","Neuromuscular medicine","Pediatrics"],"Account":["Peripheral Neuropathy"]},"synonyms":["madsam"," multifocal acquired demyelinating sensory and motor neuropathy"]}