{"Name":"Magic syndrome","DiseaseID__c":"GARD:0013371","id":13371,"encodedName":"magic-syndrome","IsDeleted":false,"Disease_Name_Full__c":"Magic syndrome","Xref_IDs__c":"238850005; C0406568; MEDGEN:590513; MONDO:0017958; ORPHA:324972","USA_Estimate__c":"1,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"1 to 8,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":3,"Description_Source__c":"ORPHA:324972","Disease_Description__c":"A rare autoinflammatory syndrome characterized by the presence of features of relapsing polychondritis and Behçet's disease in the same individual. This includes cartilage inflammation of the ears, nose, throat, and rib cage, as well as recurrent oral and genital ulcers, respectively. Patients may also present ocular involvement (in particular anterior uveitis or scleritis), arthritis, fever, colitis, thrombophlebitis, central nervous system vasculitis, or, in rare cases, arterial aneurysms. Symptoms of polychondritis occur secondary to those of Behçet's disease in the vast majority of cases.","GARD_Name__c":"Magic syndrome","GARD_Synonym__c":"magic (mouth and genital ulcers inflamed cartilage) syndrome; mouth and genital ulcers with inflamed cartilage; mouth and genital ulcers with inflamed cartilage syndrome; mouth and genital ulcers-inflamed cartilage syndrome","Curated_Disease_Description_Source__c":"PlainLanguagePilotV1-Sep23","Curated_Disease_Description__c":"MAGIC syndrome is a rare autoinflammatory syndrome characterized by the presence of features of relapsing polychondritis and Behçet's disease in the same individual. It causes inflammation of the cartilage in the e ears, nose, throat, and rib cage. It can also lead to recurrent ulcers in the mouth and genitals. Some patients may also experience eye problems, joint pain, fever, colitis (inflammation of the inner lining of the colon), thrombophlebitis (a swollen vein due to a blood clot), or inflammation of blood vessels in the brain and spinal cord. In some cases, the disease can also cause arterial aneurysms. The symptoms of polychondritis usually occur after the symptoms of Behçet's disease.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"1,000","Age_at_Onset_Snippet_Text__c":"from Childhood to Adulthood","SourceID__c":"ORPHA:324972","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0017958","ORPHANET_ID__c":"ORPHA:324972","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Síndrome magic","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"síndrome magic","Spanish_GARD_Synonym__c":"cartílago inflamado con úlceras bucales y genitales","Category_Linearization__c":"ORPHA:98023","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"MAGIC syndrome is a rare autoinflammatory syndrome characterized by the presence of features of relapsing polychondritis and Behçet's disease in the same individual. It causes inflammation of the cartilage in the e ears, nose, throat, and rib cage. It can also lead to recurrent ulcers in the mouth and genitals. Some patients may also experience eye problems, joint pain, fever, colitis (inflammation of the inner lining of the colon), thrombophlebitis (a swollen vein due to a blood clot), or inflammation of blood vessels in the brain and spinal cord. In some cases, the disease can also cause arterial aneurysms. The symptoms of polychondritis usually occur after the symptoms of Behçet's disease.","Curated_Disease_Description_Source__c":"PlainLanguagePilotV1-Sep23","GARD_Synonym__c":"magic (mouth and genital ulcers inflamed cartilage) syndrome; mouth and genital ulcers with inflamed cartilage; mouth and genital ulcers with inflamed cartilage syndrome; mouth and genital ulcers-inflamed cartilage syndrome","Name":"Magic syndrome","Curated_USA_Estimate__c":"1,000","estimateUsa":"1,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Rare Autoinflammatory Conditions Community - UK","Website__c":"https://www.raccuk.com/"},{"Account_Name__c":"The International Foundation for Autoimmune & Autoinflammatory Arthritis","Website__c":"https://www.aiarthritis.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Rheumatology","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:324972"},{"Age_At_Onset__c":"Childhood","Provided_By__c":"ORPHA:324972"},{"Age_At_Onset__c":"Adolescent","Provided_By__c":"ORPHA:324972"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=590513","Source__c":"C0406568","Xref__c":"MEDGEN:590513"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0406568","Source__c":"C0406568","Xref__c":"C0406568"},{"URL__c":"https://www.orpha.net/en/disease/detail/324972","Source__c":"C0406568; MONDO:0017958; ORPHA:324972","Xref__c":"ORPHA:324972"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0017958","Source__c":"GARD:0013371","Xref__c":"MONDO:0017958"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=238850005","Source__c":"C0406568","Xref__c":"238850005"}],"tags":{"Specialist":["Rheumatology","Pediatrics"]},"synonyms":["magic (mouth and genital ulcers inflamed cartilage) syndrome"," mouth and genital ulcers with inflamed cartilage"," mouth and genital ulcers with inflamed cartilage syndrome"," mouth and genital ulcers-inflamed cartilage syndrome"]}