{"Name":"T-cell prolymphocytic leukemia","DiseaseID__c":"GARD:0013731","id":13731,"encodedName":"t-cell-prolymphocytic-leukemia","IsDeleted":false,"Disease_Name_Full__c":"T-cell prolymphocytic leukemia","Xref_IDs__c":"277545003; 277567002; C2363142; C4752; D015461; DOID:0081042; MEDGEN:391707; MONDO:0019468; ORPHA:86871","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":2,"Description_Source__c":"MONDO:0019468","Disease_Description__c":"A slow-growing type of leukemia (blood cancer) in which too many lymphocytes are found in the bone marrow and/or blood. The T-cell is specified as the defective cell line.","GARD_Name__c":"T-cell prolymphocytic leukemia","GARD_Synonym__c":"cll, t-cell; prolymphocytic leukemia of t-cell type; prolymphocytic leukemia, t-cell type; t cell chronic lymphocytic leukaemia; t cell chronic lymphocytic leukemia; t cell cll; t cell prolymphocytic leukaemia; t cell prolymphocytic leukemia; t prolymphocytic leukaemia; t prolymphocytic leukemia; t-cell chronic lymphocytic leukaemia; t-cell chronic lymphocytic leukemia; t-cell cll; t-pll","Curated_Disease_Description_Source__c":"PlainLanguagePilotV1-Sep23","Curated_Disease_Description__c":"T-cell prolymphocytic leukemia is a rare type of cancer that affects T-cells, which are a type of white blood cell. This cancer is characterized by the growth of small to medium-sized prolymphocytes that originate from post-thymic T-cells. It can affect many parts of the body, including the peripheral blood, bone marrow, lymph nodes, liver, spleen, and sometimes the skin. Patients with T-cell prolymphocytic leukemia typically experience symptoms such as an enlarged liver and spleen, swollen lymph nodes throughout the body, high white blood cell count with normal serum immunoglobulins, anemia, and low platelet count.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"as an Adult and as an Older Adult","SourceID__c":"ORPHA:86871","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0019468","ORPHANET_ID__c":"ORPHA:86871","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Leucemia prolinfocítica de células t","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"leucemia prolinfocítica de células t","Spanish_GARD_Synonym__c":"leucemia linfocítica crónica de células t; t-pll","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"T-cell prolymphocytic leukemia is a rare type of cancer that affects T-cells, which are a type of white blood cell. This cancer is characterized by the growth of small to medium-sized prolymphocytes that originate from post-thymic T-cells. It can affect many parts of the body, including the peripheral blood, bone marrow, lymph nodes, liver, spleen, and sometimes the skin. Patients with T-cell prolymphocytic leukemia typically experience symptoms such as an enlarged liver and spleen, swollen lymph nodes throughout the body, high white blood cell count with normal serum immunoglobulins, anemia, and low platelet count.","Curated_Disease_Description_Source__c":"PlainLanguagePilotV1-Sep23","GARD_Synonym__c":"cll, t-cell; prolymphocytic leukemia of t-cell type; prolymphocytic leukemia, t-cell type; t cell chronic lymphocytic leukaemia; t cell chronic lymphocytic leukemia; t cell cll; t cell prolymphocytic leukaemia; t cell prolymphocytic leukemia; t prolymphocytic leukaemia; t prolymphocytic leukemia; t-cell chronic lymphocytic leukaemia; t-cell chronic lymphocytic leukemia; t-cell cll; t-pll","Name":"T-cell prolymphocytic leukemia","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"HealthTree Foundation","Website__c":"https://healthtree.org/"},{"Account_Name__c":"Blood Cancer United","Website__c":"https://bloodcancerunited.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Hematology","Tag_Category__c":"Disease Category;Specialist","category_description":"Blood diseases affect the blood or blood-forming organs, including red blood cells, white blood cells, platelets, plasma, and bone marrow.","curated_tag_name":"Blood diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:86871"},{"Age_At_Onset__c":"Elderly","Provided_By__c":"ORPHA:86871"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=391707","Source__c":"C2363142","Xref__c":"MEDGEN:391707"},{"URL__c":"https://www.orpha.net/en/disease/detail/86871","Source__c":"C2363142; MONDO:0019468; ORPHA:86871","Xref__c":"ORPHA:86871"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0081042","Source__c":"MONDO:0019468","Xref__c":"DOID:0081042"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4752","Source__c":"C2363142; MONDO:0019468","Xref__c":"C4752"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C015461","Source__c":"C2363142; MONDO:0019468","Xref__c":"D015461"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C2363142","Source__c":"C2363142","Xref__c":"C2363142"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=277545003","Source__c":"MONDO:0019468","Xref__c":"277545003"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=277567002","Source__c":"C2363142; MONDO:0019468","Xref__c":"277567002"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=128821006","Source__c":"C2363142","Xref__c":"128821006"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019468","Source__c":"GARD:0013731","Xref__c":"MONDO:0019468"}],"tags":{"Specialist":["Cancer - Oncologist","Hematology"],"Disease Category":["Cancer","Hematology"]},"synonyms":["cll, t-cell"," prolymphocytic leukemia of t-cell type"," prolymphocytic leukemia, t-cell type"," t cell chronic lymphocytic leukaemia"," t cell chronic lymphocytic leukemia"," t cell cll"," t cell prolymphocytic leukaemia"," t cell prolymphocytic leukemia"," t prolymphocytic leukaemia"," t prolymphocytic leukemia"," t-cell chronic lymphocytic leukaemia"," t-cell chronic lymphocytic leukemia"," t-cell cll"," t-pll"]}