{"Name":"Central precocious puberty","DiseaseID__c":"GARD:0016546","id":16546,"encodedName":"central-precocious-puberty","IsDeleted":false,"Disease_Name_Full__c":"Central precocious puberty","Xref_IDs__c":"237816004; C0342543; C113217; C562787; DOID:0112308; MEDGEN:90985; MONDO:0019165; OMIMPS:176400; ORPHA:650063","USA_Estimate__c":"200,000","No_of_Specialist_Tagsa__c":1,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":"800,000 to 5,000,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0019165","Disease_Description__c":"Central precocious puberty (CPP), also referred to as gonadotropin dependent precocious puberty, is an endocrine-related developmental disease characterized by the onset of pubertal changes, with development of secondary sexual characteristics and accelerated growth and bone maturation, before the normal age of puberty (8 years in girls and 9 years in boys).","GARD_Name__c":"Central precocious puberty","GARD_Synonym__c":"cpp; gonadotropin-dependant precocious puberty; gonadotropin-dependent precocious puberty; precocious puberty, central","Curated_Disease_Description_Source__c":"MONDO:0019165","Curated_Disease_Description__c":"Central precocious puberty is a condition that causes early sexual development in girls and boys. While puberty normally starts between ages 8 and 13 in girls and between ages 9 and 14 in boys, girls with central precocious puberty begin exhibiting signs before age 8, and boys with this disorder begin before age 9. Signs of puberty include development of pubic and underarm hair, a rapid increase in height (commonly referred to as a 'growth spurt'), acne, and underarm odor. Girls also develop breasts and begin their menstrual periods. Boys have growth of the penis and testes and deepening of the voice. Because of the early growth spurt, children with central precocious puberty may be taller than their peers; however, they may stop growing abnormally early. Without proper treatment, some affected individuals are shorter in adulthood compared with other members of their family. Developing ahead of their peers can be emotionally difficult for affected individuals and may lead to psychological and behavioral problems.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"200,000","Age_at_Onset_Snippet_Text__c":null,"SourceID__c":"ORPHA:759","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0019165","ORPHANET_ID__c":"ORPHA:650063","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Pubertad precoz central rara","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"pubertad precoz central rara","Spanish_GARD_Synonym__c":"ppc rara; pubertad precoz dependiente de gonadotropina","Category_Linearization__c":"ORPHA:97978","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Central precocious puberty is a condition that causes early sexual development in girls and boys. While puberty normally starts between ages 8 and 13 in girls and between ages 9 and 14 in boys, girls with central precocious puberty begin exhibiting signs before age 8, and boys with this disorder begin before age 9. Signs of puberty include development of pubic and underarm hair, a rapid increase in height (commonly referred to as a 'growth spurt'), acne, and underarm odor. Girls also develop breasts and begin their menstrual periods. Boys have growth of the penis and testes and deepening of the voice. Because of the early growth spurt, children with central precocious puberty may be taller than their peers; however, they may stop growing abnormally early. Without proper treatment, some affected individuals are shorter in adulthood compared with other members of their family. Developing ahead of their peers can be emotionally difficult for affected individuals and may lead to psychological and behavioral problems.","Curated_Disease_Description_Source__c":"MONDO:0019165","GARD_Synonym__c":"cpp; gonadotropin-dependant precocious puberty; gonadotropin-dependent precocious puberty; precocious puberty, central","Name":"Central precocious puberty","Curated_USA_Estimate__c":"200,000","estimateUsa":"200,000"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Endocrine","Tag_Category__c":"Disease Category;Specialist","category_description":"Endocrine diseases affect hormone production or how the body responds to a specific hormone(s).","curated_tag_name":"Endocrine diseases"}],"External_Identifier_Disease__c":[{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=237816004","Source__c":"C0342543; MONDO:0019165","Xref__c":"237816004"},{"URL__c":"https://www.omim.org/phenotypicSeries/PS176400","Source__c":"MONDO:0019165","Xref__c":"OMIMPS:176400"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0342543","Source__c":"C0342543","Xref__c":"C0342543"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0112308","Source__c":"MONDO:0019165","Xref__c":"DOID:0112308"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=90985","Source__c":"C0342543","Xref__c":"MEDGEN:90985"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C562787","Source__c":"MONDO:0019165","Xref__c":"C562787"},{"URL__c":"https://www.orpha.net/en/disease/detail/650063","Source__c":"MONDO:0019165","Xref__c":"ORPHA:650063"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C113217","Source__c":"C0342543","Xref__c":"C113217"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019165","Source__c":"GARD:0016546","Xref__c":"MONDO:0019165"},{"URL__c":"https://medlineplus.gov/genetics/condition/central-precocious-puberty","Source__c":"GARD:0016546","Xref__c":"https://medlineplus.gov/genetics/condition/central-precocious-puberty"}],"tags":{"Disease Category":["Endocrine"],"Specialist":["Endocrine"]},"synonyms":["cpp"," gonadotropin-dependant precocious puberty"," gonadotropin-dependent precocious puberty"," precocious puberty, central"]}