{"Name":"Lown-Ganong-Levine syndrome","DiseaseID__c":"GARD:0016550","id":16550,"encodedName":"lown-ganong-levine-syndrome","IsDeleted":false,"Disease_Name_Full__c":"Lown-Ganong-Levine syndrome","Xref_IDs__c":"55475008; C1862387; D008151; DOID:13087; MEDGEN:354734; MONDO:0007174; OMIM:108950","USA_Estimate__c":"1,000","No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"1 to 8,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":1,"Disease_Characteristics_Score__c":3,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0007174","Disease_Description__c":"Lown-Ganong-Levine syndrome is an extremely rare conduction disorder characterized by a short PR interval (less than or equal to 120 ms) with normal QRS complex on electrocardiogram associated with the occurrence of episodes of atrial tachyarrythmias (e.g. atrial fibrillation, atrial tachycardia).","GARD_Name__c":"Lown-Ganong-Levine syndrome","GARD_Synonym__c":"atrial tachyarrhythmia with short pr interval; lgl syndrome; syndrome of short p-r interval, normal qrs complexes, and supraventricular tachycardias","Curated_Disease_Description_Source__c":"MONDO:0007174","Curated_Disease_Description__c":"Lown-Ganong-Levine syndrome is an extremely rare conduction disorder characterized by a short PR interval (less than or equal to 120 ms) with normal QRS complex on electrocardiogram associated with the occurrence of episodes of atrial tachyarrythmias (e.g. atrial fibrillation, atrial tachycardia).","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"1,000","Age_at_Onset_Snippet_Text__c":null,"SourceID__c":"ORPHA:844","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0007174","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":"ORPHA:844","Spanish_Description__c":"Es un trastorno de la conducción extremadamente infrecuente caracterizado por un intervalo PR corto (menor o igual a 120 ms) con un complejo QRS normal en el electrocardiograma asociado con la aparición de episodios de taquiarritmias auriculares (como fibrilación auricular, taquicardia auricular).","Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Lown-Ganong-Levine syndrome is an extremely rare conduction disorder characterized by a short PR interval (less than or equal to 120 ms) with normal QRS complex on electrocardiogram associated with the occurrence of episodes of atrial tachyarrythmias (e.g. atrial fibrillation, atrial tachycardia).","Curated_Disease_Description_Source__c":"MONDO:0007174","GARD_Synonym__c":"atrial tachyarrhythmia with short pr interval; lgl syndrome; syndrome of short p-r interval, normal qrs complexes, and supraventricular tachycardias","Name":"Lown-Ganong-Levine syndrome","Curated_USA_Estimate__c":"1,000","estimateUsa":"1,000"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C008151","Source__c":"MONDO:0007174","Xref__c":"D008151"},{"URL__c":"https://www.omim.org/entry/108950","Source__c":"C1862387; MONDO:0007174","Xref__c":"OMIM:108950"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A13087","Source__c":"MONDO:0007174","Xref__c":"DOID:13087"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=354734","Source__c":"C1862387","Xref__c":"MEDGEN:354734"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=55475008","Source__c":"MONDO:0007174","Xref__c":"55475008"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1862387","Source__c":"C1862387","Xref__c":"C1862387"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0007174","Source__c":"GARD:0016550","Xref__c":"MONDO:0007174"}],"Inheritance__c":["Autosomal dominant"],"GARD_Disease_Feature__c":[{"Provided_By__c":"OMIM:108950","Feature__r":{"HPO_Description__c":"Atrial fibrillation (AF) that cannot be successfully terminated by cardioversion, and longstanding (more than 1 year) AF, where cardioversion is not indicated or has not been attempted, is termed permanent.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0004754","HPO_Name__c":"Permanent atrial fibrillation","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"OMIM:108950","Feature__r":{"HPO_Description__c":"Reduced time for the PR interval (beginning of the P wave to the beginning of the QRS complex). In adults, normal values are 120 to 200 ms long.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0005165","HPO_Synonym__c":"Electrocardiographic short PR interval; Short P-R interval; Shortened PR interval on EKG","HPO_Name__c":"Shortened PR interval","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Procedure_EKG"}},{"Provided_By__c":"OMIM:108950","Feature__r":{"HPO_Description__c":"Episodes of atrial fibrillation that typically last for several hours up to one day and terminate spontaneously.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0004757","HPO_Synonym__c":"Atrial fibrillation, paroxysmal; Intermittent atrial fibrillation; Paroxysmal AF","HPO_Name__c":"Paroxysmal atrial fibrillation","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"OMIM:108950","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0006671","HPO_Name__c":"Paroxysmal atrial tachycardia","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}}],"tags":{},"synonyms":["atrial tachyarrhythmia with short pr interval"," lgl syndrome"," syndrome of short p-r interval, normal qrs complexes, and supraventricular tachycardias"]}